Gelatin-based nanoparticles and antibiotics: a new therapeutic approach for osteomyelitis?

IF 3.9 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Frontiers in Molecular Biosciences Pub Date : 2024-07-30 DOI:10.3389/fmolb.2024.1412325

Ali Sherafati Chaleshtori, Zeynab Marzhoseyni, Negin Saeedi, Rosita Azar Bahadori, Samaneh Mollazadeh, Hossein Pourghadamyari, Esmaeil Sajadimoghadam, Kazem Abbaszadeh‐Goudarzi, Amin Moradi Hasan-Abad, Reza Sharafati Chaleshtori

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Abstract

The result of infection of bone with microorganisms is osteomyelitis and septic arthritis. Methicillin-resistant Staphylococcus aureus (MRSA) is responsible for most of its cases (more than 50%). Since MRSA is resistant to many treatments, it is accompanied by high costs and numerous complications, necessitating more effective new treatments. Recently, development of gelatin nanoparticles have attracted the attention of scientists of biomedicine to itself, and have been utilized as a delivery vehicle for antibiotics because of their biocompatibility, biodegradability, and cost-effectiveness. Promising results have been reported with gelatin modification and combinations with chemical agents. Although these findings have been suggested that gelatin has the potential to be a suitable option for continuous release of antibiotics in osteomyelitis and septic arthritis treatment, they still have not become routine in clinical practices. The most deliver antibiotic using gelatin-derived composites is vancomycin which is showed the good efficacy. To date, a number of pre-clinical studies evaluated the utility of gelatin-based composites in the management of osteomyelitis. Gelatin-based composites were found to have satisfactory performance in the control of infection, as well as the promotion of bone defect repair in chronic osteomyelitis models. This review summarized the available evidence which provides a new insight into gelatin-derived composites with controlled release of antibiotics.

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明胶基纳米粒子和抗生素：骨髓炎的新疗法？

骨髓炎和化脓性关节炎是微生物感染骨骼的结果。耐甲氧西林金黄色葡萄球菌（MRSA）是大多数病例（超过 50%）的罪魁祸首。由于 MRSA 对许多治疗方法都有抗药性，因此伴随着高昂的费用和众多并发症，需要更有效的新疗法。最近，明胶纳米粒子的开发引起了生物医学科学家的关注，由于其生物相容性、生物降解性和成本效益，明胶纳米粒子已被用作抗生素的输送载体。据报道，对明胶进行改性并与化学制剂结合使用取得了可喜的成果。尽管这些研究结果表明，明胶有可能成为骨髓炎和化脓性关节炎治疗中持续释放抗生素的合适选择，但在临床实践中仍未成为常规。使用明胶衍生复合材料释放抗生素最多的是万古霉素，它具有良好的疗效。迄今为止，一些临床前研究评估了明胶基复合材料在治疗骨髓炎方面的效用。在慢性骨髓炎模型中，明胶基复合材料在控制感染和促进骨缺损修复方面的表现令人满意。这篇综述总结了现有的证据，为控制抗生素释放的明胶基复合材料提供了新的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Molecular Biosciences Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

7.20

自引率

4.00%

发文量

1361

审稿时长

14 weeks

期刊介绍： Much of contemporary investigation in the life sciences is devoted to the molecular-scale understanding of the relationships between genes and the environment — in particular, dynamic alterations in the levels, modifications, and interactions of cellular effectors, including proteins. Frontiers in Molecular Biosciences offers an international publication platform for basic as well as applied research; we encourage contributions spanning both established and emerging areas of biology. To this end, the journal draws from empirical disciplines such as structural biology, enzymology, biochemistry, and biophysics, capitalizing as well on the technological advancements that have enabled metabolomics and proteomics measurements in massively parallel throughput, and the development of robust and innovative computational biology strategies. We also recognize influences from medicine and technology, welcoming studies in molecular genetics, molecular diagnostics and therapeutics, and nanotechnology. Our ultimate objective is the comprehensive illustration of the molecular mechanisms regulating proteins, nucleic acids, carbohydrates, lipids, and small metabolites in organisms across all branches of life. In addition to interesting new findings, techniques, and applications, Frontiers in Molecular Biosciences will consider new testable hypotheses to inspire different perspectives and stimulate scientific dialogue. The integration of in silico, in vitro, and in vivo approaches will benefit endeavors across all domains of the life sciences.