Altered Functional Connectivity of the Thalamus Subregions Associated with Impaired Attention After Sleep Deprivation

IF 3 2区医学 Q2 CLINICAL NEUROLOGY

Nature and Science of Sleep Pub Date : 2024-07-29 DOI:10.2147/nss.s472323

Sitong Feng, Ziyao Wu, Sisi Zheng, Linrui Dong, Hongxiao Jia, Yanzhe Ning

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引用次数: 0

Abstract

Objective: The thalamus plays a critical role in attentional maintenance. Previous studies have revealed the dysfunction of the thalamus in attention decline after acute sleep deprivation (SD). However, the functional connectivity (FC) between the thalamus subregions and cortical regions underlying attentional impairment after acute SD remains unclear. Here, we aimed to probe the relationship between attentional function and the altered thalamocortical FC after acute SD.
Methods: In this study, 25 healthy participants with regular sleep conducted an attentional network test and received a resting-state fMRI scan before and after 24 hours of SD. Then, we analyzed the FC between the thalamus and cerebrum and relationships with attentional function in the enrolled subjects.
Results: Our results showed that the participants showed a significantly lower alerting effect, a higher executive effect, and lower accuracy after acute SD. Compared to the rested wakefulness state, we observed decreased FCs between the “somatosensory” thalamic seed and left frontal pole, right frontal pole, left middle temporal gyrus (posterior division), and right middle temporal gyrus (posterior division). Furthermore, the reduced FC between the right middle temporal gyrus and “somatosensory” thalamic seed was negatively associated with the change in orienting effect of the participants.
Conclusion: Our findings reveal that the disrupted FC between thalamus subregions and cortical regions may contribute to impaired attention after SD.

Keywords: sleep deprivation, fMRI, attention, thalamus, functional connectivity

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丘脑亚区的功能连接性改变与睡眠剥夺后的注意力受损有关

目的丘脑在注意力维持过程中起着至关重要的作用。以往的研究揭示了丘脑在急性睡眠剥夺（SD）后注意力下降过程中的功能障碍。然而，丘脑亚区与皮层区域之间的功能连接（FC）在急性睡眠剥夺（SD）后注意力受损中的基础作用仍不清楚。在此，我们旨在探究急性睡眠剥夺后注意力功能与丘脑皮层功能连接改变之间的关系：本研究中，25名睡眠规律的健康参与者在SD 24小时前后进行了注意力网络测试和静息态fMRI扫描。然后，我们分析了参试者丘脑和大脑之间的FC以及与注意功能的关系：结果：我们的研究结果表明，急性自毁后，受试者的警觉效应明显降低，执行效应明显提高，准确性明显降低。与休息清醒状态相比，我们观察到 "躯体感觉 "丘脑种子与左额极、右额极、左颞中回（后部）和右颞中回（后部）之间的FC降低。此外，右颞中回和 "体感 "丘脑种子之间的FC降低与参与者的定向效应变化呈负相关：结论：我们的研究结果表明，丘脑亚区和皮层区域之间的功能连接紊乱可能是自毁性睡眠后注意力受损的原因之一。

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来源期刊

Nature and Science of Sleep Neuroscience-Behavioral Neuroscience

CiteScore

5.70

自引率

5.90%

发文量

245

审稿时长

16 weeks

期刊介绍： Nature and Science of Sleep is an international, peer-reviewed, open access journal covering all aspects of sleep science and sleep medicine, including the neurophysiology and functions of sleep, the genetics of sleep, sleep and society, biological rhythms, dreaming, sleep disorders and therapy, and strategies to optimize healthy sleep. Specific topics covered in the journal include: The functions of sleep in humans and other animals Physiological and neurophysiological changes with sleep The genetics of sleep and sleep differences The neurotransmitters, receptors and pathways involved in controlling both sleep and wakefulness Behavioral and pharmacological interventions aimed at improving sleep, and improving wakefulness Sleep changes with development and with age Sleep and reproduction (e.g., changes across the menstrual cycle, with pregnancy and menopause) The science and nature of dreams Sleep disorders Impact of sleep and sleep disorders on health, daytime function and quality of life Sleep problems secondary to clinical disorders Interaction of society with sleep (e.g., consequences of shift work, occupational health, public health) The microbiome and sleep Chronotherapy Impact of circadian rhythms on sleep, physiology, cognition and health Mechanisms controlling circadian rhythms, centrally and peripherally Impact of circadian rhythm disruptions (including night shift work, jet lag and social jet lag) on sleep, physiology, cognition and health Behavioral and pharmacological interventions aimed at reducing adverse effects of circadian-related sleep disruption Assessment of technologies and biomarkers for measuring sleep and/or circadian rhythms Epigenetic markers of sleep or circadian disruption.