Synthesis and Study of Sorption Properties of Ca3La6(SiO4)6 Biocomposite for Targeted Delivery of 5-Fluorouracil

IF 1.8 3区 化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR
O. O. Shichalin, O. V. Kapustina, Z. E. Kornakova, S. S. Gribanova, V. Y. Mayorov, A. N. Fedorets, A. O. Lembikov, V. V. Vasilyeva, I. Y. Buravlev, V. I. Apanasevich, E. K. Papynov
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引用次数: 0

Abstract

The dispersed Ca3La6(SiO4)6 biocomposite was obtained by treating a calcium silicate sol containing 0.1, 0.3, and 0.7 mol of La3+ under hydrothermal conditions. The composition, morphology, and structure of the biocomposite were studied by powder X-ray diffraction, SEM, and EDS methods. The reaction products (CaSiO3, CaLa4(SiO4)3O, Ca3La6(SiO4)6) depending on the La3+ concentration were determined. The structural characteristics of biocomposite powders with different La3+ contents were investigated by BET and DFT methods. The sorption characteristics of the materials towards 5-fluorouracil were studied depending on pH. The highest sorption capacity (0.768 mg/g at pH 3) was found for the Ca3La6(SiO4)6 sample containing 0.3 mol of La3+. Additionally, the biocompatible properties of biocomposite samples in contact with artificial blood plasma were evaluated by establishing the key changes in their composition, morphology, and structure upon the formation of the apatite bioactive phase on the accessible surface of the samples. These results hold promise for further development of new sorption materials, including biomaterials, for targeted drug delivery with a potential for practical application.

Abstract Image

用于 5-氟尿嘧啶靶向给药的 Ca3La6(SiO4)6 生物复合材料的合成及其吸附特性研究
摘要 在水热条件下处理含0.1、0.3和0.7 mol La3+的硅酸钙溶胶,得到了分散的Ca3La6(SiO4)6生物复合材料。通过粉末 X 射线衍射、扫描电镜和 EDS 方法研究了生物复合材料的成分、形态和结构。测定了不同 La3+ 浓度下的反应产物(CaSiO3、CaLa4(SiO4)3O、Ca3La6(SiO4)6)。采用 BET 和 DFT 方法研究了不同 La3+ 含量的生物复合粉末的结构特征。研究了材料对 5-氟尿嘧啶的吸附特性取决于 pH 值。发现含有 0.3 摩尔 La3+ 的 Ca3La6(SiO4)6 样品的吸附容量最高(pH 值为 3 时为 0.768 毫克/克)。此外,还评估了与人造血浆接触的生物复合材料样品的生物相容性,确定了样品可接触表面形成磷灰石生物活性相后,样品的成分、形态和结构发生的关键变化。这些结果为进一步开发新的吸附材料(包括生物材料)提供了希望,这些材料具有实际应用的潜力,可用于靶向给药。
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来源期刊
Russian Journal of Inorganic Chemistry
Russian Journal of Inorganic Chemistry 化学-无机化学与核化学
CiteScore
3.10
自引率
38.10%
发文量
237
审稿时长
3 months
期刊介绍: Russian Journal of Inorganic Chemistry is a monthly periodical that covers the following topics of research: the synthesis and properties of inorganic compounds, coordination compounds, physicochemical analysis of inorganic systems, theoretical inorganic chemistry, physical methods of investigation, chemistry of solutions, inorganic materials, and nanomaterials.
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