Macrophages: A missing key in cardiac tissue engineering for sustained vascularization

IF 19.8 1区医学 Q1 CELL & TISSUE ENGINEERING

Cell stem cell Pub Date : 2024-08-01 DOI:10.1016/j.stem.2024.07.001

引用次数: 0

Abstract

Macrophages regulate angiogenesis, repair, conduction, and homeostasis in heart tissue. Landau et al.¹ demonstrate that incorporating primitive macrophages into engineered heart tissues significantly promotes long-term vascularization and cardiac maturation. This advance demonstrates the importance of resident immune-vascular microenvironments in cardiac tissue engineering, marking an important step forward for heart-on-chip technologies.

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巨噬细胞：心脏组织工程中缺失的关键--持续血管化

巨噬细胞调节心脏组织的血管生成、修复、传导和稳态。Landau 等人1 证明，将原始巨噬细胞纳入工程心脏组织可显著促进长期血管化和心脏成熟。这一进展证明了常驻免疫血管微环境在心脏组织工程中的重要性，标志着芯片心脏技术向前迈出了重要一步。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell stem cell 生物-细胞生物学

CiteScore

37.10

自引率

2.50%

发文量

151

审稿时长

42 days

期刊介绍： Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.