Exosome-Mediated Brain Tumor Diagnostics from Peripheral Fluids: A Review of Clinical Data.

Meghna Bhattacharyya, Justin Gold, Ryan Moncman, Clint Badger, Amber Valeri, Joseph Georges, Steven Yocom
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引用次数: 0

Abstract

Definitive diagnoses in neuro-oncology often require invasive procedures, such as surgical biopsies to obtain tissue for histopathologic and molecular interrogation. Patients with small lesions that may respond to nonsurgical treatments, such as chemoradiation, may nevertheless undergo surgery with potential risks to obtain diagnostic tissue. A means for noninvasively obtaining diagnostic information from brain tumors may improve patient care by limiting the need for surgery. Molecular evaluation of exosomes may provide such a means. Exosomes are small vesicles excreted from tumor cells that contain molecular information. Isolation of these vesicles from peripheral fluids, such as blood and urine, may provide diagnostic information for rendering a definitive diagnosis. Here, we review current clinical data for exosome-mediated brain tumor diagnostics.

从外周体液中获得外泌体介导的脑肿瘤诊断方法:临床数据回顾。
神经肿瘤学的确诊通常需要进行侵入性手术,如通过手术活检获取组织进行组织病理学和分子检测。病灶较小的患者可能对化疗等非手术治疗方法有反应,但为了获取诊断组织,他们仍可能接受具有潜在风险的手术。从脑肿瘤中非侵入性地获取诊断信息的方法可限制手术需求,从而改善对患者的护理。对外泌体进行分子评估可能就是这样一种方法。外泌体是肿瘤细胞排出的小囊泡,含有分子信息。从血液和尿液等外周体液中分离这些小泡可为明确诊断提供诊断信息。在此,我们回顾了外泌体介导的脑肿瘤诊断的现有临床数据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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