The Neurophysiological Effects of Theta Burst Stimulation as Measured by Electroencephalography: A Systematic Review

IF 5.7 2区医学 Q1 NEUROSCIENCES

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging Pub Date : 2024-11-01 DOI:10.1016/j.bpsc.2024.07.018

Bridgette E. Speranza , Aron T. Hill , Michael Do , Andris Cerins , Peter H. Donaldson , Pushpal Desarker , Lindsay M. Oberman , Sushmit Das , Peter G. Enticott , Melissa Kirkovski

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引用次数: 0

Abstract

Theta burst stimulation (TBS) is a noninvasive brain stimulation technique that can modulate neural activity. The effect of TBS on regions beyond the motor cortex remains unclear. With increased interest in applying TBS to nonmotor regions for research and clinical purposes, these effects must be understood and characterized. We synthesized the electrophysiological effects of a single session of TBS, as indexed by electroencephalography (EEG) and concurrent transcranial magnetic stimulation and EEG, in nonclinical participants. We reviewed 79 studies that administered either continuous TBS or intermittent TBS protocols. Broadly, continuous TBS suppressed and intermittent TBS facilitated evoked response component amplitudes. Response to TBS as measured by spectral power and connectivity was much more variable. Variability increased in the presence of task stimuli. There was a large degree of heterogeneity in the research methodology across studies. Additionally, the effect of individual differences on TBS response has been insufficiently investigated. Future research investigating the effects of TBS as measured by EEG must consider methodological and individual factors that may affect TBS outcomes.

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用脑电图测量 Theta 波段刺激的神经生理学效应：系统回顾。

θ脉冲刺激（TBS）是一种非侵入性脑部刺激技术，可以调节神经活动。TBS 对运动皮层以外区域的影响仍不清楚。随着人们对将 TBS 应用于非运动区域的研究和临床目的的兴趣日益浓厚，必须了解这些影响并确定其特征。我们综合分析了单次 TBS 对非临床参与者的电生理效应，这些效应以脑电图 (EEG) 和同时经颅磁刺激和脑电图 (TMS-EEG) 为指标。我们回顾了 79 项研究，这些研究采用了连续 TBS（cTBS）或间歇 TBS（iTBS）方案。总的来说，cTBS 抑制了诱发反应成分的振幅，而 iTBS 则促进了诱发反应成分的振幅。通过频谱功率和连通性测量的 TBS 反应则更加多变。在有任务刺激的情况下，变异性会增加。不同研究的研究方法存在很大程度的异质性。此外，个体差异对 TBS 反应的影响也未得到充分研究。未来通过脑电图测量 TBS 效果的研究必须考虑可能影响 TBS 结果的方法和个体因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging Neuroscience-Biological Psychiatry

CiteScore

10.40

自引率

1.70%

发文量

247

审稿时长

30 days

期刊介绍： Biological Psychiatry: Cognitive Neuroscience and Neuroimaging is an official journal of the Society for Biological Psychiatry, whose purpose is to promote excellence in scientific research and education in fields that investigate the nature, causes, mechanisms, and treatments of disorders of thought, emotion, or behavior. In accord with this mission, this peer-reviewed, rapid-publication, international journal focuses on studies using the tools and constructs of cognitive neuroscience, including the full range of non-invasive neuroimaging and human extra- and intracranial physiological recording methodologies. It publishes both basic and clinical studies, including those that incorporate genetic data, pharmacological challenges, and computational modeling approaches. The journal publishes novel results of original research which represent an important new lead or significant impact on the field. Reviews and commentaries that focus on topics of current research and interest are also encouraged.