The role of ribosomal DNA methylation in embryonic development, aging and diseases.

IF 4.2 2区 生物学 Q1 GENETICS & HEREDITY
Fei Yang, Xutong Guo, Yiming Bao, Rujiao Li
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引用次数: 0

Abstract

The ribosomal DNA (rDNA) constitutes a remarkably conserved DNA sequence within species, located in the area of the nucleolus, and responsible for coding three major types of rRNAs (18S, 5.8S and 28S). While historical investigations into rDNA focused on its structure and coding capabilities, recent research has turned to explore its functional roles in various biological processes. In this review, we summarize the main findings of rDNA methylation with embryonic development, aging and diseases in multiple species, including epigenetic alterations, related biological processes and potential applications of rDNA methylation. We present an overview of current related research and identify gaps in this field.

核糖体 DNA 甲基化在胚胎发育、衰老和疾病中的作用。
核糖体 DNA(rDNA)是物种内极为保守的 DNA 序列,位于核仁区域,负责编码三种主要类型的 rRNA(18S、5.8S 和 28S)。过去对 rDNA 的研究主要集中在其结构和编码能力上,而最近的研究则转向探索其在各种生物过程中的功能作用。在这篇综述中,我们总结了 rDNA 甲基化与多个物种的胚胎发育、衰老和疾病有关的主要发现,包括表观遗传学改变、相关生物过程和 rDNA 甲基化的潜在应用。我们概述了当前的相关研究,并指出了这一领域的差距。
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来源期刊
Epigenetics & Chromatin
Epigenetics & Chromatin GENETICS & HEREDITY-
CiteScore
7.00
自引率
0.00%
发文量
35
审稿时长
1 months
期刊介绍: Epigenetics & Chromatin is a peer-reviewed, open access, online journal that publishes research, and reviews, providing novel insights into epigenetic inheritance and chromatin-based interactions. The journal aims to understand how gene and chromosomal elements are regulated and their activities maintained during processes such as cell division, differentiation and environmental alteration.
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