Immunomodulatory signalling networks in glioblastoma multiforme: a comprehensive review of therapeutic approaches.

IF 3.4 3区生物学 Q3 CELL BIOLOGY

Human Cell Pub Date : 2024-09-01 Epub Date: 2024-07-31 DOI:10.1007/s13577-024-01112-8

Souhrid Sarkar, Somi Patranabis

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引用次数: 0

Abstract

Glioblastoma multiforme is a very aggressive type of cancer with high mortality and poor prognosis worldwide. Advanced treatment options with an understanding of the molecules and signalling mechanisms involved in this type of cancer have the potential to increase targeted therapy and decrease off-target effects, resistance, and recurrence. Glioblastoma multiforme (GBM) presents a complex tumour microenvironment with numerous cellular components and an extracellular matrix comprising multiple components. A deeper understanding of these components and corresponding signalling pathways can increase the success of immune checkpoint inhibitors in the treatment of GBM. The discovery of specific molecular changes and biomarkers has led to the investigation of tailored treatments for individual patients. Combination therapies targeting multiple pathways or utilizing different modalities are emerging as a promising strategy albeit with challenges in drug delivery to the brain. The review presents a comprehensive update of the various immunomodulatory signalling networks in GBM and highlights the corresponding therapeutic approaches by targeting them.

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多形性胶质母细胞瘤的免疫调节信号网络：治疗方法综述。

多形性胶质母细胞瘤是一种侵袭性很强的癌症，在全球范围内死亡率高、预后差。通过了解这种癌症所涉及的分子和信号机制，先进的治疗方案有可能增加靶向治疗，减少脱靶效应、耐药性和复发。多形性胶质母细胞瘤（GBM）具有复杂的肿瘤微环境，其中包含多种细胞成分和由多种成分组成的细胞外基质。深入了解这些成分和相应的信号通路可以提高免疫检查点抑制剂治疗 GBM 的成功率。特定分子变化和生物标志物的发现促使人们开始研究针对个体患者的定制疗法。针对多种途径或利用不同模式的联合疗法正在成为一种前景广阔的策略，尽管在向脑部给药方面存在挑战。本综述全面介绍了 GBM 中各种免疫调节信号网络的最新情况，并重点介绍了针对这些信号网络的相应治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Human Cell CELL BIOLOGY-

CiteScore

5.90

自引率

2.30%

发文量

176

审稿时长

4.5 months

期刊介绍： Human Cell is the official English-language journal of the Japan Human Cell Society. The journal serves as a forum for international research on all aspects of the human cell, encompassing not only cell biology but also pathology, cytology, and oncology, including clinical oncology. Embryonic stem cells derived from animals, regenerative medicine using animal cells, and experimental animal models with implications for human diseases are covered as well. Submissions in any of the following categories will be considered: Research Articles, Cell Lines, Rapid Communications, Reviews, and Letters to the Editor. A brief clinical case report focusing on cellular responses to pathological insults in human studies may also be submitted as a Letter to the Editor in a concise and short format. Not only basic scientists but also gynecologists, oncologists, and other clinical scientists are welcome to submit work expressing new ideas or research using human cells.