Improved ovarian adiponectin system expression in polycystic ovary syndrome treated with exenatide.

IF 1.8 Q3 OBSTETRICS & GYNECOLOGY
Asma Vatankhah, Mohabbat Jamhiri, Sima Vatankhah, Keivan Lorian, Mohammad Ebrahim Rezvani, Mahin Izadi
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引用次数: 0

Abstract

Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder that can cause infertility. This experimental study was conducted to elucidate the role of adiponectin signaling in rats with PCOS treated with exenatide. Twenty-eight adult female Wistar rats were divided into four groups of seven. The normal group did not receive any drug. The PCOS+vehicle (Veh) group received estradiol valerate to induce PCOS, then was divided into PCOS +E50 and PCOS+E100 groups and treated with 50 or 100 mg/kg doses of exenatide, respectively. The mRNA expression of adiponectin and adiponectin receptor 1 (Adipo-R1) was evaluated using a semi-quantitative real-time polymerase chain reaction. The results indicated that the level of adiponectin diminished in the PCOS rats while exenatide increased adiponectin expression at both doses. Adiponectin receptor mRNA levels were higher in the PCOS rats than in the normal rats (p<0.05). In addition, exenatide decreased the levels of Adipo-R1 expression. Taken together, our results showed that exenatide may improve PCOS characteristics in rats through the molecular regulation of adiponectin and its receptor.

用艾塞那肽治疗多囊卵巢综合征可改善卵巢脂肪生成素系统的表达。
多囊卵巢综合征(PCOS)是一种常见的内分泌和代谢疾病,可导致不孕。本实验研究旨在阐明艾塞那肽治疗多囊卵巢综合征大鼠体内脂肪连接素信号转导的作用。28 只成年雌性 Wistar 大鼠被分为四组,每组 7 只。正常组不接受任何药物治疗。PCOS+车辆(Veh)组接受戊酸雌二醇诱导PCOS,然后分为PCOS+E50组和PCOS+E100组,分别给予50或100 mg/kg剂量的艾塞那肽治疗。采用半定量实时聚合酶链反应评估了脂肪连通素和脂肪连通素受体1(Adipo-R1)的mRNA表达。结果表明,在两种剂量下,PCOS 大鼠体内的脂肪生成素水平都有所下降,而艾塞那肽则增加了脂肪生成素的表达。多囊卵巢综合症大鼠的脂肪生成素受体 mRNA 水平高于正常大鼠(p
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CiteScore
3.30
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