Novel insights on the positive correlation between sense and antisense pairs on gene expression.

IF 6.4 2区 生物学 Q1 CELL BIOLOGY
Subhadeep Das, Maria Paula Zea Rojas, Elizabeth J Tran
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Abstract

A considerable proportion of the eukaryotic genome undergoes transcription, leading to the generation of noncoding RNA molecules that lack protein-coding information and are not subjected to translation. These noncoding RNAs (ncRNAs) are well recognized to have essential roles in several biological processes. Long noncoding RNAs (lncRNAs) represent the most extensive category of ncRNAs found in the human genome. Much research has focused on investigating the roles of cis-acting lncRNAs in the regulation of specific target gene expression. In the majority of instances, the regulation of sense gene expression by its corresponding antisense pair occurs in a negative (discordant) manner, resulting in the suppression of the target genes. The notion that a negative correlation exists between sense and antisense pairings is, however, not universally valid. In fact, several recent studies have reported a positive relationship between corresponding cis antisense pairs within plants, budding yeast, and mammalian cancer cells. The positive (concordant) correlation between anti-sense and sense transcripts leads to an increase in the level of the sense transcript within the same genomic loci. In addition, mechanisms such as altering chromatin structure, the formation of R loops, and the recruitment of transcription factors can either enhance transcription or stabilize sense transcripts through their antisense pairs. The primary objective of this work is to provide a comprehensive understanding of both aspects of antisense regulation, specifically focusing on the positive correlation between sense and antisense transcripts in the context of eukaryotic gene expression, including its implications towards cancer progression. This article is categorized under: RNA Processing > 3' End Processing Regulatory RNAs/RNAi/Riboswitches > Regulatory RNAs.

Abstract Image

有义和反义配对基因表达正相关的新见解。
真核生物基因组中有相当一部分要进行转录,从而产生缺乏蛋白质编码信息且不需要翻译的非编码 RNA 分子。这些非编码 RNA(ncRNA)被公认在多个生物过程中发挥着重要作用。长非编码 RNA(lncRNA)是人类基因组中发现的最广泛的一类 ncRNA。许多研究都集中在研究顺式作用的 lncRNA 在调控特定靶基因表达中的作用。在大多数情况下,相应的反义配对对有义基因表达的调控是以负相关(不和谐)的方式进行的,从而导致靶基因受到抑制。然而,有义和反义配对之间存在负相关关系的观点并非普遍有效。事实上,最近有几项研究报告称,植物、萌发酵母和哺乳动物癌细胞中相应的顺反义配对之间存在正相关关系。反义转录本与有义转录本之间的正相关(一致)关系会导致同一基因组位点内有义转录本水平的提高。此外,染色质结构的改变、R 环的形成以及转录因子的招募等机制都会通过反义对加强转录或稳定有义转录本。这项研究的主要目的是全面了解反义调控的两个方面,特别是在真核生物基因表达中有义和反义转录本之间的正相关性,包括其对癌症进展的影响。本文归类于RNA 处理 > 3' 端处理 调控 RNAs/RNAi/Riboswitches > 调控 RNAs。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
14.80
自引率
4.10%
发文量
67
审稿时长
6-12 weeks
期刊介绍: WIREs RNA aims to provide comprehensive, up-to-date, and coherent coverage of this interesting and growing field, providing a framework for both RNA experts and interdisciplinary researchers to not only gain perspective in areas of RNA biology, but to generate new insights and applications as well. Major topics to be covered are: RNA Structure and Dynamics; RNA Evolution and Genomics; RNA-Based Catalysis; RNA Interactions with Proteins and Other Molecules; Translation; RNA Processing; RNA Export/Localization; RNA Turnover and Surveillance; Regulatory RNAs/RNAi/Riboswitches; RNA in Disease and Development; and RNA Methods.
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