Explore the genetic exposure to alopecia areata.

IF 2 4区 医学 Q3 DERMATOLOGY
Shaoyi Peng, Yang Yang, Yilong Man, Dianfei Long, Lei Wang, Kaiyuan Li, Peng Liu
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引用次数: 0

Abstract

Background: Alopecia areata is an autoimmune hair loss disorder with an incompletely understood etiology. Although trace elements, serum metabolites, and inflammatory factors are implicated in the disease, the potential causal relationships between these factors and alopecia areata require further investigation.

Methods: This study employed Mendelian randomization (MR), utilizing data from genome-wide association studies, to explore the causal relationships between 15 trace elements, 1400 serum metabolites, and 91 inflammatory factors and alopecia areata. The analysis was conducted using the inverse variance weighted (IVW) method complemented by various sensitivity analyses, including Cochran's Q test, MR-Egger regression intercept test, MR-PRESSO global test, and leave-one-out analysis, to assess the robustness of the results.

Results: MR analysis indicated a negative correlation between copper levels and the risk of developing alopecia areata (odds ratio = 0.86, 95% confidence interval: 0.75-0.99, p = 0.041). Additionally, causal relationships were identified between 15 serum metabolites and 6 inflammatory factors and the risk of alopecia areata (IVW, all p values < 0.05).

Conclusion: This study provides genetic evidence of the relationships between trace elements, serum metabolites, and alopecia areata, underscoring the potential value of targeted therapeutic strategies and preventive measures. Future research should expand to diverse populations and further explore the specific roles of these biomarkers in the disease mechanism.

探索遗传因素对斑秃的影响。
背景:斑秃是一种自身免疫性脱发疾病,病因尚不完全清楚。虽然微量元素、血清代谢物和炎症因子与该病有关,但这些因素与脱发之间的潜在因果关系还需要进一步研究:本研究采用孟德尔随机化方法(MR),利用全基因组关联研究的数据,探讨了 15 种微量元素、1400 种血清代谢物和 91 种炎症因子与斑秃之间的因果关系。分析采用了反方差加权(IVW)法,并辅以各种敏感性分析,包括 Cochran's Q 检验、MR-Egger 回归截距检验、MR-PRESSO 全局检验和排除分析,以评估结果的稳健性:MR分析表明,铜水平与罹患斑秃的风险呈负相关(几率比=0.86,95%置信区间:0.75-0.99,P=0.041)。此外,还发现 15 种血清代谢物和 6 种炎症因子与秃发症风险之间存在因果关系(IVW,所有 p 值均为结论):本研究提供了微量元素、血清代谢物和斑秃之间关系的遗传学证据,强调了有针对性的治疗策略和预防措施的潜在价值。未来的研究应扩展到不同人群,并进一步探索这些生物标志物在疾病机制中的具体作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Skin Research and Technology
Skin Research and Technology 医学-皮肤病学
CiteScore
3.30
自引率
9.10%
发文量
95
审稿时长
6-12 weeks
期刊介绍: Skin Research and Technology is a clinically-oriented journal on biophysical methods and imaging techniques and how they are used in dermatology, cosmetology and plastic surgery for noninvasive quantification of skin structure and functions. Papers are invited on the development and validation of methods and their application in the characterization of diseased, abnormal and normal skin. Topics include blood flow, colorimetry, thermography, evaporimetry, epidermal humidity, desquamation, profilometry, skin mechanics, epiluminiscence microscopy, high-frequency ultrasonography, confocal microscopy, digital imaging, image analysis and computerized evaluation and magnetic resonance. Noninvasive biochemical methods (such as lipids, keratin and tissue water) and the instrumental evaluation of cytological and histological samples are also covered. The journal has a wide scope and aims to link scientists, clinical researchers and technicians through original articles, communications, editorials and commentaries, letters, reviews, announcements and news. Contributions should be clear, experimentally sound and novel.
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