Anatomic Features of the Lamina Cribrosa and Optic Disc in Ocular Hypertension, Glaucoma and Healthy Eyes.

IF 2 4区 医学 Q2 OPHTHALMOLOGY
Journal of Glaucoma Pub Date : 2024-11-01 Epub Date: 2024-08-02 DOI:10.1097/IJG.0000000000002470
Mine Esen Baris, Suzan Guven
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引用次数: 0

Abstract

Prcis: Central lamina cribrosa thickness (LCT) was found to be higher in eyes with ocular hypertension (OHT) compared with primary open angle glaucoma (POAG) and healthy controls (HCs).

Objective: To evaluate the anatomic features of lamina cribrosa (LC) and the optic disc (OD) using swept-source optical coherence tomography (OCT) in eyes with OHT.

Materials and methods: Treatment naive eyes with OHT and POAG and healthy eyes were included. All eyes underwent a complete ophthalmological examination in addition to swept-source OCT of the OD. Anatomic features of LC, including central LCT, LC depth, prelaminar depth (PLD), and prelaminar tissue thickness, were measured manually using the internal caliper function of the OCT device and compared within groups. OD ovality, disc-foveal angle, and OD torsion were measured on colored photographs, using imageJ software.

Results: Seventy-one eyes of 37 patients in the OHT group, 41 eyes of 26 patients in the POAG group, and 30 eyes of 30 patients in the HC group were enrolled in the study. Groups were similar in age and sex distribution. Central LCT was significantly higher in the OHT group, compared with HCs (333.8 ± 50.5 vs 304.5 ± 46.3 µm, P = 0.02) and POAG group (286.7 ± 140.4, P = 0.001). PLD and LC depth were both highest in POAG (282.3 ± 145.5 µm and 471.3 ± 195.2 µm), followed by OHT (244.8 ± 30.2 µm and 440.7 ± 18.7 µm) and HCs (170.1 ± 152.6 µm and 412.8 ± 80 µm), only the difference between POAG and HCs in PLD was statistically significant ( P = 0.03). Prelaminar tissue thickness, OD torsion, disc-foveal angle, and disc ovality showed no significant difference.

Conclusion: LC was significantly thicker in eyes with OHT, compared with POAG and HCs. This finding may be relevant to optic nerve protection from high intraocular pressure in patients with OHT.

眼压过高、青光眼和健康眼睛的颅底角膜和视盘解剖特征
摘要目的:使用扫源光学相干断层扫描(OCT)评估眼底高血压(OHT)患者眼底中央楔形层(LC)和视盘(OD)的解剖特征:研究对象包括OHT和原发性开角型青光眼(POAG)的未接受治疗的患者以及健康的患者。所有眼球均接受了全面的眼科检查和视盘扫源 OCT 检查。使用 OCT 设备的内部卡尺功能手动测量 LC 的解剖特征,包括中央 LC 厚度(LCT)、LC 深度(LCD)、层前深度(PLD)和层前组织厚度(PLTT),并在组内进行比较。使用 imageJ 软件在彩色照片上测量视盘椭圆度、视盘-眼窝角和视盘扭转:结果:37 名 OHT 组患者中的 71 只眼睛、26 名 POAG 组患者中的 41 只眼睛和 30 名健康对照组(HCs)患者中的 30 只眼睛参加了研究。各组的年龄和性别分布相似。与 HCs(333.8±50.5µm vs. 304.5±46.3µm,P=0.02)和 POAG 组(286.7±140.4,P=0.001)相比,OHT 组的中心 LCT 明显更高。POAG组的PLD和LCD均最高(282.3±145.5µm和471.3±195.2µm),其次是OHT组(244.8±30.2µm和440.7±18.7µm)和HC组(170.1±152.6µm和412.8±80µm),只有POAG组和HC组的PLD差异有统计学意义(P=0.03)。结论:结论:与 POAG 和 HCs 相比,OHT 患者的 LC 明显更厚。结论:与 POAG 和 HCs 相比,OHT 患者的 LC 明显增厚,这一发现可能与眼压过高对视神经的保护有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Glaucoma
Journal of Glaucoma 医学-眼科学
CiteScore
4.20
自引率
10.00%
发文量
330
审稿时长
4-8 weeks
期刊介绍: The Journal of Glaucoma is a peer reviewed journal addressing the spectrum of issues affecting definition, diagnosis, and management of glaucoma and providing a forum for lively and stimulating discussion of clinical, scientific, and socioeconomic factors affecting care of glaucoma patients.
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