Deep cervical lymph nodes in Parkinson's disease and atypical Parkinson's disease: A potential ultrasound biomarker for differential diagnosis.

IF 2.6 Q2 CLINICAL NEUROLOGY
Journal of Central Nervous System Disease Pub Date : 2024-07-29 eCollection Date: 2024-01-01 DOI:10.1177/11795735241259429
Zhaoying Dong, Xinyi Du, Ling Wang, Xiaoya Zou, Hongzhou Zuo, Yong Yan, Guojun Chen, Oumei Cheng, Yong Zhang
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Abstract

Background: Parkinson's disease (PD) is a common degenerative disease caused by abnormal accumulation of α-synuclein. The glymphatic pathway is essential for removing macromolecular proteins including α-synuclein from the brain, which flows into deep cervical lymph nodes (DCLNs) through meningeal lymphatics. As a terminal station for the cerebral lymphatic system drainage, DCLNs can be easily assessed clinically.

Objectives: Although the drainage function of the cerebral lymphatic system is impaired in PD, the correlation between DCLNs and PD remains unknown.

Design: Single-center retrospective cross-sectional study.

Methods: The size of the DCLNs were measured using ultrasound. The Movement Disorder Society Sponsored Revision Unified Parkinson's Disease Rating Scale and other scales were used to assess PD motor and non-motor symptoms.

Results: Compared with the healthy control (HC) and the atypical Parkinson's disease (AP) groups, the size of the second and third DCLNs in the Parkinson's disease (PD) group was significantly smaller (P < .05). The width diameter of the third DCLN (DCLN3(y)) was significantly smaller in the PD group than in the AP group (P = .014). DCLN3(y) combined with a variety of clinical features improved the sensitivity of AP identification (sensitivity = .813).

Conclusion: DCLNs were able to distinguish HC, PD and AP and were mainly located in Robbins ΙΙA level. PD and AP were associated with different factors that influenced the size of the DCLNs. DCLN3(y) plays an important role in differentiating PD from AP, which, combined with other clinical features, has the ability to distinguish PD from AP; in particular, the sensitivity of AP diagnosis was improved.

帕金森病和非典型帕金森病的颈深淋巴结:用于鉴别诊断的潜在超声生物标记。
背景:帕金森病(PD)是一种常见的退行性疾病,由α-突触核蛋白的异常积累引起。脑淋巴途径对清除脑内包括α-突触核蛋白在内的大分子蛋白质至关重要,α-突触核蛋白通过脑膜淋巴管流入深颈淋巴结(DCLNs)。作为脑淋巴系统引流的终点站,DCLNs 很容易进行临床评估:目的:虽然帕金森病患者脑淋巴系统的引流功能受损,但 DCLNs 与帕金森病的相关性仍不清楚:设计:单中心回顾性横断面研究:方法:使用超声波测量DCLNs的大小。结果:与健康对照组(HC)相比,DCLNs与帕金森病的关系更为密切:结果:与健康对照组(HC)和非典型帕金森病(AP)组相比,帕金森病(PD)组第二和第三个DCLNs的尺寸明显较小(P < .05)。帕金森病组第三个 DCLN 的宽度直径(DCLN3(y))明显小于帕金森病组(P = .014)。DCLN3(y)与各种临床特征相结合,提高了AP鉴定的灵敏度(灵敏度 = .813):结论:DCLNs能区分HC、PD和AP,主要位于罗宾斯ΙΙA水平。PD和AP与影响DCLNs大小的不同因素有关。DCLN3(y)在区分PD和AP中起着重要作用,结合其他临床特征,DCLN3(y)具有区分PD和AP的能力,尤其是提高了诊断AP的敏感性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.90
自引率
0.00%
发文量
39
审稿时长
8 weeks
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