Increased cardiometabolic risk and prevalence of ascending aorta dilation in patients with nonfunctioning adrenal incidentaloma: a retrospective propensity score-matched study

IF 4.3 2区 医学 Q1 PERIPHERAL VASCULAR DISEASE
Mirko Parasiliti-Caprino, Anna Roux, Lorenzo Campioni, Matteo Procopio, Stefano Arata, Jacopo Giannelli, Martina Bollati, Chiara Bima, Chiara Lopez, Fabio Bioletto, Ezio Ghigo, Emanuela Arvat, Mauro Maccario, Roberta Giordano
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引用次数: 0

Abstract

The cardiometabolic implications of Non-Functioning Adrenal Incidentaloma (NFAI) is still matter of debate. This study takes a novel approach to analyze this association, accounting for the influence of various confounding factors. We present the findings of a retrospective, cross-sectional, and case-control study. Data from all NFAI patients in primary prevention, referred to the University of Turin between 2000 and 2023, were collected and compared with subjects without adrenal disease, using propensity score matching analysis. A total of 1997 patients were included (906 patients with NFAI; 1091 controls). Adrenal tumor group was associated with high levels of cardiovascular risk scores in both univariate and multiple linear regression analyses (Progetto CUORE: EC 11.00, 95% CI 2.72–44.46, p = 0.001; SCORE: EC 1.97, 95% CI 1.01–3.81, p = 0.046). Regarding cardiometabolic complications, multivariable logistic regression revealed an independent association between NFAI and ascending aorta dilation (OR 4.64, 95% CI 2.24–9.63, p = 0.000), after adjusting for age, sex, smoking status, metabolic syndrome, number of antihypertensive drugs, estimated glomerular filtration rate (eGFR), and normetanephrine levels. Propensity score matching analysis (1:1 matching ratio), based on the same logistic regression model, confirmed the association of NFAI with aortic dilation (β = 0.083, 95% CI 0.008–0.157, p = 0.030). No significant associations were found with metabolic syndrome, type II diabetes, eGFR <60 mL/min/1.73 m2, microalbuminuria, atrial fibrillation, or hypertensive heart disease. This study suggests that patients with NFAI face increased cardiometabolic risk and high prevalence of ascending aorta dilation. Routine evaluation of NFAI patients should include thorough cardiovascular assessment and consideration of treatments aimed at reducing cardiovascular risk.

Abstract Image

Abstract Image

无功能性肾上腺偶发瘤患者的心脏代谢风险增加和升主动脉扩张的发生率:一项倾向评分匹配的回顾性研究。
非功能性肾上腺偶发瘤(NFAI)对心脏代谢的影响仍存在争议。本研究采用了一种新方法来分析这种关联,并考虑了各种混杂因素的影响。我们展示了一项回顾性、横断面和病例对照研究的结果。研究收集了 2000 年至 2023 年期间转诊到都灵大学的所有 NFAI 一级预防患者的数据,并采用倾向得分匹配分析法与无肾上腺疾病的受试者进行了比较。共纳入了 1997 名患者(906 名 NFAI 患者;1091 名对照组)。在单变量和多元线性回归分析中,肾上腺肿瘤组与高水平的心血管风险评分相关(Progetto CUORE:EC 11.00,95% CI 2.72-44.46,p = 0.001;SCORE:EC:1.97,95% CI:1.01-3.81,p = 0.046)。在心脏代谢并发症方面,多变量逻辑回归显示,在调整年龄、性别、吸烟状况、代谢综合征、服用降压药次数、估计肾小球滤过率(eGFR)和正常肾上腺素水平后,NFAI 与升主动脉扩张之间存在独立关联(OR 4.64,95% CI 2.24-9.63,p = 0.000)。基于同一逻辑回归模型的倾向得分匹配分析(1:1 匹配比)证实了 NFAI 与主动脉扩张的关系(β = 0.083,95% CI 0.008-0.157,p = 0.030)。与代谢综合征、II 型糖尿病、eGFR 2、微量白蛋白尿、心房颤动或高血压性心脏病无明显关联。这项研究表明,NFAI 患者面临着更高的心脏代谢风险和升主动脉扩张的高发病率。对 NFAI 患者的常规评估应包括全面的心血管评估和考虑旨在降低心血管风险的治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Hypertension Research
Hypertension Research 医学-外周血管病
CiteScore
7.40
自引率
16.70%
发文量
249
审稿时长
3-8 weeks
期刊介绍: Hypertension Research is the official publication of the Japanese Society of Hypertension. The journal publishes papers reporting original clinical and experimental research that contribute to the advancement of knowledge in the field of hypertension and related cardiovascular diseases. The journal publishes Review Articles, Articles, Correspondence and Comments.
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