Incidence and prevalence of Alzheimer's disease in China: a systematic review and meta-analysis.

IF 7.7 1区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

European Journal of Epidemiology Pub Date : 2024-07-01 Epub Date: 2024-08-01 DOI:10.1007/s10654-024-01144-2

Qianqian Ji, Jingqi Chen, Yafei Li, Enxiang Tao, Yiqiang Zhan

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引用次数: 0

Abstract

As China faces demographic shifts and socioeconomic changes, the burden of Alzheimer's disease (AD) and associated cognitive impairments is increasing dramatically, with significant implications for public health and the economy. This systematic review and meta-analysis aims to provide a comprehensive assessment of the prevalence and incidence of AD across China. Drawing from an extensive search of international and Chinese databases up to August 27, 2023, including PubMed, Embase, and the Cochrane Library, we synthesized data from 105 studies. Our analysis reveals a combined prevalence of AD of 3.48% within a sample of 626,276 elderly individuals and an incidence rate of 7.90 per 1000 person-years. Subgroup and meta-regression analyses highlight age and gender as pivotal factors influencing these epidemiological patterns. Notably, significant heterogeneity exists due to variations in diagnostic criteria and study quality, impacting the comparability of findings. This meta-analysis underscores the need for continued research into demographic and modifiable risk factors influencing AD, while emphasizing standardized reporting practices to address these limitations and improve the understanding of AD's challenge in China.

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中国阿尔茨海默病的发病率和流行率：系统回顾和荟萃分析。

随着中国人口结构的变化和社会经济的变革，阿尔茨海默病（AD）和相关认知障碍的负担正在急剧增加，对公共卫生和经济产生了重大影响。本系统综述和荟萃分析旨在对中国阿尔茨海默病的患病率和发病率进行全面评估。我们广泛检索了截至 2023 年 8 月 27 日的国际和中文数据库，包括 PubMed、Embase 和 Cochrane 图书馆，综合了 105 项研究的数据。我们的分析显示，在 626,276 名老年人样本中，AD 的综合患病率为 3.48%，发病率为每千人年 7.90 例。分组和元回归分析显示，年龄和性别是影响这些流行病学模式的关键因素。值得注意的是，由于诊断标准和研究质量的差异，存在着明显的异质性，影响了研究结果的可比性。这项荟萃分析强调了继续研究影响AD的人口统计学因素和可改变的风险因素的必要性，同时强调了标准化的报告方法，以解决这些局限性并提高人们对AD在中国所面临挑战的认识。

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来源期刊

European Journal of Epidemiology 医学-公共卫生、环境卫生与职业卫生

CiteScore

21.40

自引率

1.50%

发文量

109

审稿时长

6-12 weeks

期刊介绍： The European Journal of Epidemiology, established in 1985, is a peer-reviewed publication that provides a platform for discussions on epidemiology in its broadest sense. It covers various aspects of epidemiologic research and statistical methods. The journal facilitates communication between researchers, educators, and practitioners in epidemiology, including those in clinical and community medicine. Contributions from diverse fields such as public health, preventive medicine, clinical medicine, health economics, and computational biology and data science, in relation to health and disease, are encouraged. While accepting submissions from all over the world, the journal particularly emphasizes European topics relevant to epidemiology. The published articles consist of empirical research findings, developments in methodology, and opinion pieces.