Effects of combined aerobic and resistance training on the inflammatory profile of children with overweight/obesity: A randomized clinical trial

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Obesity Pub Date : 2024-07-31 DOI:10.1111/ijpo.13152

Jose J. Gil-Cosano, Abel Plaza-Florido, Luis Gracia-Marco, Jairo H. Migueles, Cristina Cadenas-Sanchez, Marcos Olvera-Rojas, Esther Ubago-Guisado, Idoia Labayen, Alejandro Lucia, Francisco B. Ortega

{"title":"Effects of combined aerobic and resistance training on the inflammatory profile of children with overweight/obesity: A randomized clinical trial","authors":"Jose J. Gil-Cosano, Abel Plaza-Florido, Luis Gracia-Marco, Jairo H. Migueles, Cristina Cadenas-Sanchez, Marcos Olvera-Rojas, Esther Ubago-Guisado, Idoia Labayen, Alejandro Lucia, Francisco B. Ortega","doi":"10.1111/ijpo.13152","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>We assessed the effects of a 20-week combined (aerobic and resistance) exercise training programme on the inflammatory profile of prepubertal children with overweight or obesity.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Totally 109 participants (10.1 ± 1.1 years, 41% girls) were randomly allocated to an exercise or control group. Adiponectin, C-reactive protein, epidermal growth factor, insulin-like growth factor-1, interleukin (IL)-1β, IL-6, leptin, tumour necrosis factor-α and vascular endothelial growth factor A (VEGFA) were analysed in plasma. Total white blood cell (WBC) count and immune subpopulations (eosinophils, basophils, neutrophils, lymphocytes and monocytes) were also determined.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>No intervention effect was found for any of the analysed biomarkers (all <i>p</i> ≥ 0.05). We observed a significant sex by intervention interaction for IL-1β (<i>p</i> = 0.03). When stratifying the sample by sex, the exercise programme induced a significant effect on IL-1β levels (mean <i>Z</i>-score difference, 0.66 [95% confidence interval 0.32–1.01]) in girls, but not in boys. A lower number of girls in the exercise group showed a meaningful reduction in IL-1β (i.e., ≥0.2 standard deviations) than in the control group (15% vs. 85%, <i>p</i> = 0.01).</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>This exercise programme failed to improve the inflammatory profile in prepubertal children with overweight/obesity. Future studies should explore the effect of longer exercise interventions and in combination with diet.</p>\n </section>\n </div>","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":"19 10","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ijpo.13152","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pediatric Obesity","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/ijpo.13152","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PEDIATRICS","Score":null,"Total":0}

引用次数: 0

Abstract

Background

We assessed the effects of a 20-week combined (aerobic and resistance) exercise training programme on the inflammatory profile of prepubertal children with overweight or obesity.

Methods

Totally 109 participants (10.1 ± 1.1 years, 41% girls) were randomly allocated to an exercise or control group. Adiponectin, C-reactive protein, epidermal growth factor, insulin-like growth factor-1, interleukin (IL)-1β, IL-6, leptin, tumour necrosis factor-α and vascular endothelial growth factor A (VEGFA) were analysed in plasma. Total white blood cell (WBC) count and immune subpopulations (eosinophils, basophils, neutrophils, lymphocytes and monocytes) were also determined.

Results

No intervention effect was found for any of the analysed biomarkers (all p ≥ 0.05). We observed a significant sex by intervention interaction for IL-1β (p = 0.03). When stratifying the sample by sex, the exercise programme induced a significant effect on IL-1β levels (mean Z-score difference, 0.66 [95% confidence interval 0.32–1.01]) in girls, but not in boys. A lower number of girls in the exercise group showed a meaningful reduction in IL-1β (i.e., ≥0.2 standard deviations) than in the control group (15% vs. 85%, p = 0.01).

Conclusions

This exercise programme failed to improve the inflammatory profile in prepubertal children with overweight/obesity. Future studies should explore the effect of longer exercise interventions and in combination with diet.

Abstract Image

查看原文本刊更多论文

有氧训练和阻力训练相结合对超重/肥胖儿童炎症特征的影响：随机临床试验

背景：我们评估了为期 20 周的综合（有氧和阻力）运动训练计划对青春期前超重或肥胖儿童炎症特征的影响：共有 109 名参与者（10.1 ± 1.1 岁，41% 为女孩）被随机分配到运动组或对照组。分析血浆中的脂肪连素、C反应蛋白、表皮生长因子、胰岛素样生长因子-1、白细胞介素（IL）-1β、IL-6、瘦素、肿瘤坏死因子-α和血管内皮生长因子A（VEGFA）。还测定了白细胞总数和免疫亚群（嗜酸性粒细胞、嗜碱性粒细胞、中性粒细胞、淋巴细胞和单核细胞）：在所分析的生物标志物中未发现干预效应（所有 p 均≥0.05）。我们观察到，IL-1β 存在明显的性别干预交互作用（p = 0.03）。按性别对样本进行分层时，运动项目对女孩的 IL-1β 水平有显著影响（平均 Z 分数差异为 0.66 [95% 置信区间为 0.32-1.01]），但对男孩没有影响。与对照组相比，运动组中 IL-1β 显著下降（即≥0.2 个标准差）的女孩人数较少（15% 对 85%，P = 0.01）：该运动计划未能改善青春期前超重/肥胖儿童的炎症状况。今后的研究应探讨更长时间的运动干预以及与饮食相结合的效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Pediatric Obesity PEDIATRICS-

CiteScore

7.30

自引率

5.30%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Pediatric Obesity is a peer-reviewed, monthly journal devoted to research into obesity during childhood and adolescence. The topic is currently at the centre of intense interest in the scientific community, and is of increasing concern to health policy-makers and the public at large. Pediatric Obesity has established itself as the leading journal for high quality papers in this field, including, but not limited to, the following: Genetic, molecular, biochemical and physiological aspects of obesity – basic, applied and clinical studies relating to mechanisms of the development of obesity throughout the life course and the consequent effects of obesity on health outcomes Metabolic consequences of child and adolescent obesity Epidemiological and population-based studies of child and adolescent overweight and obesity Measurement and diagnostic issues in assessing child and adolescent adiposity, physical activity and nutrition Clinical management of children and adolescents with obesity including studies of treatment and prevention Co-morbidities linked to child and adolescent obesity – mechanisms, assessment, and treatment Life-cycle factors eg familial, intrauterine and developmental aspects of child and adolescent obesity Nutrition security and the "double burden" of obesity and malnutrition Health promotion strategies around the issues of obesity, nutrition and physical activity in children and adolescents Community and public health measures to prevent overweight and obesity in children and adolescents.