Advances and Opportunities Concerning Nucleation Measurement and Control Technology in Crystallization

IF 3.1 3区化学 Q2 CHEMISTRY, APPLIED

Organic Process Research & Development Pub Date : 2024-07-30 DOI:10.1021/acs.oprd.4c00182

Fangkun Zhang, Aozhe Meng, Yan Long, Zai-Qun Yu, Shuai Yu, Baoming Shan, Xue Z. Wang, Qilei Xu

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Abstract

Nucleation as a unique phenomenon in the crystallization process has always been a hot topic. With the development of nucleation theory and process analysis technology (PAT), nucleation control technology (NCT) has been widely applied in industrial crystallization processes. This paper provides a comprehensive review of advancements in nucleation measurement and control technologies within crystallization processes, systematically analyzing the principles, advantages, disadvantages, and application scopes of various NCTs, and particularly the factors affecting nucleation and nucleation-assisted technologies, including ultrasound, gassing, and membranes, are elaborated. These technologies are crucial for managing the unpredictable nature of nucleation to improve the consistency and quality of crystalline products. These advanced or novel control technologies are very attractive in providing continuous and stable high-purity seeds without externally adding additional seeds and have proven to be effective alternative methods for generating internal seeds. In addition, the challenges and opportunities were pointed out from the stability, controllability, and consistency of nucleation to promoting the efficient development of crystallization technology. NCTs play a vital role in industrial applications by ensuring control over the size, purity, and morphology of crystals. This review also explains the application of NCTs in industrial scenarios, positioning these technologies as essential for the advancement of various industrial applications.

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有关结晶中成核测量和控制技术的进展与机遇

成核作为结晶过程中的一种独特现象，一直是一个热门话题。随着成核理论和过程分析技术（PAT）的发展，成核控制技术（NCT）已在工业结晶过程中得到广泛应用。本文全面回顾了结晶过程中成核测量和控制技术的进展，系统分析了各种 NCT 的原理、优缺点和应用范围，特别是阐述了影响成核的因素和成核辅助技术，包括超声、掺气和膜。这些技术对于管理成核的不可预测性以提高结晶产品的一致性和质量至关重要。这些先进或新颖的控制技术在提供连续稳定的高纯度种子方面极具吸引力，无需从外部添加额外的种子，而且已被证明是生成内部种子的有效替代方法。此外，还从成核的稳定性、可控性和一致性等方面指出了促进结晶技术高效发展所面临的挑战和机遇。通过确保对晶体大小、纯度和形态的控制，NCT 在工业应用中发挥着重要作用。本综述还解释了 NCT 在工业场景中的应用，将这些技术定位为推动各种工业应用的关键。

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来源期刊

Organic Process Research & Development 化学-应用化学

CiteScore

6.90

自引率

14.70%

发文量

251

审稿时长

2 months

期刊介绍： The journal Organic Process Research & Development serves as a communication tool between industrial chemists and chemists working in universities and research institutes. As such, it reports original work from the broad field of industrial process chemistry but also presents academic results that are relevant, or potentially relevant, to industrial applications. Process chemistry is the science that enables the safe, environmentally benign and ultimately economical manufacturing of organic compounds that are required in larger amounts to help address the needs of society. Consequently, the Journal encompasses every aspect of organic chemistry, including all aspects of catalysis, synthetic methodology development and synthetic strategy exploration, but also includes aspects from analytical and solid-state chemistry and chemical engineering, such as work-up tools，process safety, or flow-chemistry. The goal of development and optimization of chemical reactions and processes is their transfer to a larger scale; original work describing such studies and the actual implementation on scale is highly relevant to the journal. However, studies on new developments from either industry, research institutes or academia that have not yet been demonstrated on scale, but where an industrial utility can be expected and where the study has addressed important prerequisites for a scale-up and has given confidence into the reliability and practicality of the chemistry, also serve the mission of OPR&D as a communication tool between the different contributors to the field.