Microfluidic programmable strategies for channels and flow

IF 6.1 2区 工程技术 Q1 BIOCHEMICAL RESEARCH METHODS
Lab on a Chip Pub Date : 2024-07-31 DOI:10.1039/D4LC00423J
Yongxian Song, Yijiang Zhou, Kai Zhang, Zhaoxuan Fan, Fei Zhang and Mingji Wei
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引用次数: 0

Abstract

This review summarizes programmable microfluidics, an advanced method for precise fluid control in microfluidic technology through microchannel design or liquid properties, referring to microvalves, micropumps, digital microfluidics, multiplexers, micromixers, slip-, and block-based configurations. Different microvalve types, including electrokinetic, hydraulic/pneumatic, pinch, phase-change and check valves, cater to diverse experimental needs. Programmable micropumps, such as passive and active micropumps, play a crucial role in achieving precise fluid control and automation. Due to their small size and high integration, microvalves and micropumps are widely used in medical devices and biological analysis. In addition, this review provides an in-depth exploration of the applications of digital microfluidics, multiplexed microfluidics, and mixer-based microfluidics in the manipulation of liquid movement, mixing, and splitting. These methodologies leverage the physical properties of liquids, such as capillary forces and dielectric forces, to achieve precise control over fluid dynamics. SlipChip technology, which branches into rotational SlipChip and translational SlipChip, controls fluid through sliding motion of the microchannel. On the other hand, innovative designs in microfluidic systems pursue better modularity, reconfigurability and ease of assembly. Different assembly strategies, from one-dimensional assembly blocks and two-dimensional Lego®-style blocks to three-dimensional reconfigurable modules, aim to enhance flexibility and accessibility. These technologies enhance user-friendliness and accessibility by offering integrated control systems, making them potentially usable outside of specialized technical labs. Microfluidic programmable strategies for channels and flow hold promising applications in biomedical research, chemical analysis and drug screening, providing theoretical and practical guidance for broader utilization in scientific research and practical applications.

Abstract Image

用于通道和流动的微流体可编程策略
可编程微流控技术是一种通过微通道设计或液体特性对微流控技术中的流体进行精确控制的先进方法,本综述概述了微阀、微泵、数字微流控技术、多路复用器、微混合器、滑阀和基于块的配置。不同类型的微阀,包括电动阀、液压/气动阀、夹阀、相变阀和止回阀,可满足不同的实验需求。可编程微泵(如被动微泵和主动微泵)在实现精确流体控制和自动化方面发挥着至关重要的作用。由于体积小、集成度高,微阀和微泵被广泛应用于医疗设备和生物分析领域。此外,本综述还深入探讨了数字微流体技术、多路复用微流体技术和基于混合器的微流体技术在液体运动、混合和分裂操作中的应用。这些方法利用液体的物理特性,如毛细力和介电力,实现对液体动力学的精确控制。SlipChip 技术分为旋转 SlipChip 和平移 SlipChip,通过微通道的滑动运动控制液体。另一方面,微流体系统的创新设计追求更好的模块化、可重构性和装配简便性。从一维装配块、二维乐高积木到三维可重构模块,不同的装配策略旨在提高灵活性和易用性。这些技术通过提供集成控制系统,提高了用户友好性和易用性,使其有可能在专业技术实验室之外使用。针对通道和流动的微流体可编程策略在生物医学研究、化学分析和药物筛选方面有着广阔的应用前景,为科学研究和实际应用的更广泛利用提供了理论和实践指导。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Lab on a Chip
Lab on a Chip 工程技术-化学综合
CiteScore
11.10
自引率
8.20%
发文量
434
审稿时长
2.6 months
期刊介绍: Lab on a Chip is the premiere journal that publishes cutting-edge research in the field of miniaturization. By their very nature, microfluidic/nanofluidic/miniaturized systems are at the intersection of disciplines, spanning fundamental research to high-end application, which is reflected by the broad readership of the journal. Lab on a Chip publishes two types of papers on original research: full-length research papers and communications. Papers should demonstrate innovations, which can come from technical advancements or applications addressing pressing needs in globally important areas. The journal also publishes Comments, Reviews, and Perspectives.
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