Cleavage-independent GSDME activation by UVC

IF 17.3 1区生物学 Q1 CELL BIOLOGY

Nature Cell Biology Pub Date : 2024-07-31 DOI:10.1038/s41556-024-01470-3

Ellie Zhang, Liam Healy, Gang Du, Hao Wu

引用次数: 0

Abstract

Gasdermins (GSDMs) are mediators of cell death that trigger membrane lysis. A study shows that full-length GSDME induces pyroptosis after ultraviolet irradiation, involving GSDME PARylation that releases autoinhibition and lipid reactive oxygen species that promote pore formation. This study adds insights on how GSDMs can be activated non-canonically.

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不依赖于裂解的紫外线激活 GSDME

气敏素（GSDMs）是细胞死亡的介质，可引发膜裂解。一项研究表明，紫外线照射后，全长 GSDME 会诱导热昏迷，其中涉及 GSDME PARylation，它能释放促进孔形成的自抑制和脂质活性氧。这项研究进一步揭示了 GSDM 如何被非规范激活。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Cell Biology 生物-细胞生物学

CiteScore

28.40

自引率

0.90%

发文量

219

审稿时长

3 months

期刊介绍： Nature Cell Biology, a prestigious journal, upholds a commitment to publishing papers of the highest quality across all areas of cell biology, with a particular focus on elucidating mechanisms underlying fundamental cell biological processes. The journal's broad scope encompasses various areas of interest, including but not limited to: -Autophagy -Cancer biology -Cell adhesion and migration -Cell cycle and growth -Cell death -Chromatin and epigenetics -Cytoskeletal dynamics -Developmental biology -DNA replication and repair -Mechanisms of human disease -Mechanobiology -Membrane traffic and dynamics -Metabolism -Nuclear organization and dynamics -Organelle biology -Proteolysis and quality control -RNA biology -Signal transduction -Stem cell biology