Angiogenesis-elicited spectral responses of early invasive skin melanoma: Implications for the evaluation of lesion progression

IF 2 3区 物理与天体物理 Q3 BIOCHEMICAL RESEARCH METHODS
Gladimir V. G. Baranoski, Petri M. Varsa
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引用次数: 0

Abstract

Early invasive skin melanoma (EISM) associated with partial tumor invasion to the thin and optically complex papillary dermis (PD) represents a critical stage before the onset of metastasis. EISM lesions may be accompanied by angiogenesis, which can alter the PD's blood and fibril contents. A comprehensive understanding about these interconnected processes is essential for enhancing the efficacy of EISM optical evaluation methodologies. Employing a first-principles computational approach supported by measured data, we systematically assess the impact that angiogenesis can have on the EISM's spectral responses. Our findings indicate that these responses are discernibly affected by angiogenesis under distinct physiological conditions, with more substantial tissue alterations leading to accentuated spectral changes in the 550–600 nm region. Accordingly, we propose the use of a customized low-cost spectral index to monitor these processes. Furthermore, our investigation provides a high-fidelity in silico platform for interdisciplinary research on the photobiology of evolving skin melanomas.

Abstract Image

早期浸润性皮肤黑色素瘤的血管生成诱导光谱反应:对评估病变进展的意义。
早期浸润性皮肤黑色素瘤(EISM)伴有肿瘤部分侵入薄而光学结构复杂的真皮乳头层(PD),是转移开始前的一个关键阶段。EISM病变可能伴有血管生成,这会改变真皮乳头的血液和纤维内容。全面了解这些相互关联的过程对于提高 EISM 光学评估方法的有效性至关重要。在测量数据的支持下,我们采用第一原理计算方法,系统地评估了血管生成对 EISM 光谱响应的影响。我们的研究结果表明,在不同的生理条件下,血管生成会对这些响应产生明显的影响,组织的实质性改变会导致 550-600 纳米区域的光谱变化加剧。因此,我们建议使用定制的低成本光谱指数来监测这些过程。此外,我们的研究还为不断演变的皮肤黑色素瘤的光生物学跨学科研究提供了一个高保真硅学平台。
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来源期刊
Journal of Biophotonics
Journal of Biophotonics 生物-生化研究方法
CiteScore
5.70
自引率
7.10%
发文量
248
审稿时长
1 months
期刊介绍: The first international journal dedicated to publishing reviews and original articles from this exciting field, the Journal of Biophotonics covers the broad range of research on interactions between light and biological material. The journal offers a platform where the physicist communicates with the biologist and where the clinical practitioner learns about the latest tools for the diagnosis of diseases. As such, the journal is highly interdisciplinary, publishing cutting edge research in the fields of life sciences, medicine, physics, chemistry, and engineering. The coverage extends from fundamental research to specific developments, while also including the latest applications.
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