Homologous recombination deficiency status predicts response to immunotherapy-based treatment in non-small cell lung cancer patients.

IF 2.3 3区医学 Q3 ONCOLOGY

Thoracic Cancer Pub Date : 2024-09-01 Epub Date: 2024-07-30 DOI:10.1111/1759-7714.15408

Ai Gao, Xin Wang, Jing Wang, Diansheng Zhong, Linlin Zhang

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引用次数: 0

Abstract

Background: Homologous recombination deficiency (HRD) is a biomarker that predicts response to ovarian cancer treatment with poly (ADP-ribose) polymerase (PARP) inhibitors or breast cancer treatment with first-line platinum-based chemotherapy. However, there are few studies on the prognosis of lung cancer patients treated with immune checkpoint inhibitor (ICI) therapy using HRD as a biomarker.

Methods: We studied the relationship between HRD status and the effectiveness of first-line ICI-based therapy in EGFR/ALK wild-type metastatic non-small cell lung cancer patients (NSCLC) patients.

Results: This study included 22 treatment naïve NSCLC patients. The HRD score ranged from -26.37 to 92.34, with an average of 24.57. Based on analysis of the progression-free survival (PFS) data from the included NSCLC patients, threshold traversal was carried out. HRD (+) was defined as an HRD score of 31 or higher. Kaplan-Meier PFS survival analysis showed prolonged median PFS (mPFS) in NSCLC patients with HRD (+) versus HRD (-) (N/A vs. 7.0 ms, log-rank p = 0.029; HR 0.20, 95% CI: 0.04-0.96, likelihood-ratio p = 0.03). In patients with PD-L1 TPS ≥50% and HRD score ≥31 (co-status high), the mPFS was temporarily not reached during the follow-up period. In patients with PD-L1 TPS <1% and HRD score <31, the mPFS was 3 ms. Cox regression analysis showed that the hazard ratio of the co-status was 0.14 (95% CI: 0.04-0.54), which was a good prognostic factor, and the prognostic effect of co-status was better than that of HRD score alone.

Conclusion: The HRD status can be identified as an independent significance in NSCLC patients treated with first-line ICI-based therapy.

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同源重组缺陷状态可预测非小细胞肺癌患者对基于免疫疗法的治疗的反应。

背景：同源重组缺陷（HRD同源重组缺陷（HRD）是一种生物标志物，可预测卵巢癌多聚（ADP-核糖）聚合酶（PARP）抑制剂治疗或乳腺癌一线铂类化疗的反应。然而，将HRD作为生物标记物来预测接受免疫检查点抑制剂（ICI）治疗的肺癌患者的预后的研究却很少：方法：我们研究了表皮生长因子受体（EGFR）/ALK野生型转移性非小细胞肺癌（NSCLC）患者的HRD状态与基于ICI的一线治疗效果之间的关系：本研究纳入了22名治疗前未接受治疗的NSCLC患者。HRD评分范围为-26.37至92.34，平均为24.57。根据对纳入的 NSCLC 患者无进展生存期（PFS）数据的分析，进行了阈值遍历。HRD（+）的定义是HRD得分达到或超过31分。卡普兰-梅耶PFS生存分析显示，HRD（+）与HRD（-）相比，NSCLC患者的中位PFS（mPFS）延长（N/A vs. 7.0 ms, log-rank p = 0.029; HR 0.20, 95% CI: 0.04-0.96, likelihood-ratio p = 0.03）。在PD-L1 TPS≥50%且HRD评分≥31分（共同状态高）的患者中，mPFS在随访期间暂时未达到。PD-L1 TPS 患者的结论在接受基于 ICI 的一线治疗的 NSCLC 患者中，HRD 状态具有独立的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Thoracic Cancer ONCOLOGY-RESPIRATORY SYSTEM

CiteScore

5.20

自引率

3.40%

发文量

439

审稿时长

2 months

期刊介绍： Thoracic Cancer aims to facilitate international collaboration and exchange of comprehensive and cutting-edge information on basic, translational, and applied clinical research in lung cancer, esophageal cancer, mediastinal cancer, breast cancer and other thoracic malignancies. Prevention, treatment and research relevant to Asia-Pacific is a focus area, but submissions from all regions are welcomed. The editors encourage contributions relevant to prevention, general thoracic surgery, medical oncology, radiology, radiation medicine, pathology, basic cancer research, as well as epidemiological and translational studies in thoracic cancer. Thoracic Cancer is the official publication of the Chinese Society of Lung Cancer, International Chinese Society of Thoracic Surgery and is endorsed by the Korean Association for the Study of Lung Cancer and the Hong Kong Cancer Therapy Society. The Journal publishes a range of article types including: Editorials, Invited Reviews, Mini Reviews, Original Articles, Clinical Guidelines, Technological Notes, Imaging in thoracic cancer, Meeting Reports, Case Reports, Letters to the Editor, Commentaries, and Brief Reports.