Assessing the impact of severe acute respiratory syndrome coronavirus 2 infection on hematological parameters.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-07-31 DOI:10.1093/trstmh/trae047

Badi A Alotaibi, Jehad A Aldali, Hamzah J Aldali, Ali Alaseem, Abdulaziz M Almuqrin, Abdulrahman Alshalani, Hamood AlSudais, Nasser A Alshehri, Nasser B Alamar, Mogtba A Alhejji

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引用次数: 0

Abstract

Background: The current study is a retrospective study designed to evaluate changes in complete blood count and coagulation parameters in adult coronavirus disease 2019 (COVID-19) patients at a prominent Saudi tertiary center to predict disease severity and mortality.

Methods: The cohort consisted of 74 800 adult patients divided into four groups based on a COVID-19 test and the patient's sex: 35 985 in the female negative COVID-19 group, 23 278 in the male negative COVID-19 group, 8846 in the female positive COVID-19 group and 6691 in the male positive COVID-19 group.

Results: Patients with COVID-19 demonstrated decreased white blood cell counts and increased red blood cell counts. Also, COVID-19-positive participants exhibited more prolonged partial thromboplastin time and lower D-dimer levels than those of COVID-19-negative subjects (p<0.05). The study also revealed gender-dependent impacts on platelet counts, implying a possible relationship with the greater infection mortality rate in men than in women (p<0.001). In addition, the study found a link between changes in coagulation test results and death in COVID-19 patients (p<0.001). The evidence regarding the effects of COVID-19 on blood cell counts and coagulation, on the other hand, is conflicting, most likely due to variances in study populations and the timing of testing postinfection.

Conclusions: According to the findings, COVID-19-related alterations in blood cell count and clotting ability may be risk factors for death.

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评估严重急性呼吸系统综合征冠状病毒 2 感染对血液学参数的影响。

研究背景本研究是一项回顾性研究，旨在评估沙特一家著名的三级中心2019年冠状病毒病（COVID-19）成人患者全血细胞计数和凝血参数的变化，以预测疾病的严重程度和死亡率：研究对象包括74 800名成年患者，根据COVID-19检测结果和患者性别分为四组：女性COVID-19阴性组35 985人，男性COVID-19阴性组23 278人，女性COVID-19阳性组8846人，男性COVID-19阳性组6691人：结果：COVID-19 患者的白细胞计数减少，红细胞计数增加。此外，与 COVID-19 阴性受试者相比，COVID-19 阳性受试者的部分凝血活酶时间更长，D-二聚体水平更低：根据研究结果，与 COVID-19 相关的血细胞计数和凝血能力的改变可能是导致死亡的风险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.