Role of micronutrients in the symptoms of fibromyalgia: a review of the literature and analysis of an Italian female sample.

IF 3.3 4区医学 Q1 Medicine

European review for medical and pharmacological sciences Pub Date : 2024-07-01 DOI:10.26355/eurrev_202407_36579

M G Tarsitano, G Dolcini, C Pandozzi, F Greco, C Iannuncelli, C Conte, E Giannetta, M Di Franco

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Abstract

Objective: Fibromyalgia (FM) is a multifactorial disease characterized principally by chronic, widespread pain impairing a patient's quality of life. The management of FM requires a multidisciplinary approach that combines pharmacological and non-pharmacological strategies. Growing evidence suggests a potential beneficial role of micronutrients such as minerals and vitamins. Overall, the role of these supplements remains controversial, but clinical trials on vitamin D, vitamin B12, magnesium, and iron supplementation seem to provide promising results. The aim of this study was to investigate their role in an Italian female sample.

Subjects and methods: An exploratory cross-sectional study was done to assess the association of selected micronutrients with symptoms of FM by using the Fibromyalgia Impact Questionnaire (FIQ) in twenty consecutive female patients with FM. A literature review was also conducted.

Results: FIQ results revealed that vitamin D and magnesium deficiency appear to play a role in FM symptoms, mainly in physical function and stiffness. From the literature review, only two studies investigating the role of micronutrients in FM were retrieved.

Conclusions: Screening for micronutrient deficiencies in FM patients and supplementing them when levels are low might help counteract FM symptoms.

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微量营养素在纤维肌痛症状中的作用：文献综述和意大利女性样本分析。

目的：纤维肌痛（FM）是一种多因素疾病，主要表现为慢性、广泛性疼痛，影响患者的生活质量。纤维肌痛的治疗需要结合药物和非药物疗法的多学科方法。越来越多的证据表明，矿物质和维生素等微量营养素具有潜在的有益作用。总体而言，这些补充剂的作用仍存在争议，但关于维生素 D、维生素 B12、镁和铁补充剂的临床试验似乎提供了有希望的结果。本研究旨在调查意大利女性样本中这些补充剂的作用：本研究采用纤维肌痛影响问卷（Fibromyalgia Impact Questionnaire，FIQ）对连续20名女性纤维肌痛患者进行了一项探索性横断面研究，以评估特定微量营养素与纤维肌痛症状之间的关系。同时还进行了文献综述：FIQ结果显示，维生素D和镁的缺乏似乎对FM症状有影响，主要是身体功能和僵硬。在文献回顾中，仅检索到两项研究调查了微量营养素在 FM 中的作用：结论：对 FM 患者进行微量营养素缺乏筛查，并在微量营养素水平较低时补充微量营养素，可能有助于缓解 FM 症状。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European review for medical and pharmacological sciences 医学-药学

CiteScore

5.30

自引率

6.10%

发文量

906

审稿时长

2-4 weeks

期刊介绍： European Review for Medical and Pharmacological Sciences, a fortnightly journal, acts as an information exchange tool on several aspects of medical and pharmacological sciences. It publishes reviews, original articles, and results from original research. The purposes of the Journal are to encourage interdisciplinary discussions and to contribute to the advancement of medicine. European Review for Medical and Pharmacological Sciences includes: -Editorials- Reviews- Original articles- Trials- Brief communications- Case reports (only if of particular interest and accompanied by a short review)