The association between ethylene oxide and testosterone in the United States population: a cross-sectional study based on the National Health and Nutrition Examination Survey (NHANES) 2013-2016.

IF 3.7 3区医学 Q2 Medicine

Endocrine Pub Date : 2024-11-01 Epub Date: 2024-07-31 DOI:10.1007/s12020-024-03979-x

Shangqi Cao, Linghao Meng, Hexiang Bai, Weixiao Yang, Xu Hu, Xiang Li

{"title":"The association between ethylene oxide and testosterone in the United States population: a cross-sectional study based on the National Health and Nutrition Examination Survey (NHANES) 2013-2016.","authors":"Shangqi Cao, Linghao Meng, Hexiang Bai, Weixiao Yang, Xu Hu, Xiang Li","doi":"10.1007/s12020-024-03979-x","DOIUrl":null,"url":null,"abstract":"Purpose: Ethylene oxide (EO) is a prevalent industrial contaminant found in the environment and is related to various diseases such as cancers and hypertension. To the best of our knowledge, the association between EO and testosterone has not been explored. The aim of this article was to evaluate the relationship between EO and total testosterone (TT) in the United States population.Methods: In this study, hemoglobin ethylene oxide (HbEO) levels were utilized to evaluate the exposure to EO. The data of this study were collected from National Health and Nutrition Examination Survey (NHANES) 2013-2016. A total of 3300 participants were enrolled in this study and were separated into 5 groups based on the quintile of HbEO. Weighted multivariable logistic regression was used to assess the association between HbEO and TT. Subgroup analysis was conducted to investigate the connection between HbEO and TT in different stratifications.Results: In the results, there was a positive relationship between log10-transformed HbEO and TT in the fully adjusted model [β = 37.08, 95% confidence interval (CI): 18.15-56.01, p = 0.004]. After log10-transformed HbEO transferred into a categorical variable based on the quintiles (Q1-Q5), the positive association remained in the highest group (Q5) compared to the lowest group (Q1) [β = 46.09, 95%CI: 12.29-79.90, p = 0.013]. Moreover, subgroup analysis demonstrated that the positive connection between log10-transformed HbEO and TT was stronger in males than females.Conclusion: The level of HbEO was positively related to TT in the U.S. population and the relation was more obvious in men compared to women.","PeriodicalId":11572,"journal":{"name":"Endocrine","volume":" ","pages":"850-859"},"PeriodicalIF":3.7000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endocrine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s12020-024-03979-x","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/7/31 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: Ethylene oxide (EO) is a prevalent industrial contaminant found in the environment and is related to various diseases such as cancers and hypertension. To the best of our knowledge, the association between EO and testosterone has not been explored. The aim of this article was to evaluate the relationship between EO and total testosterone (TT) in the United States population.

Methods: In this study, hemoglobin ethylene oxide (HbEO) levels were utilized to evaluate the exposure to EO. The data of this study were collected from National Health and Nutrition Examination Survey (NHANES) 2013-2016. A total of 3300 participants were enrolled in this study and were separated into 5 groups based on the quintile of HbEO. Weighted multivariable logistic regression was used to assess the association between HbEO and TT. Subgroup analysis was conducted to investigate the connection between HbEO and TT in different stratifications.

Results: In the results, there was a positive relationship between log₁₀-transformed HbEO and TT in the fully adjusted model [β = 37.08, 95% confidence interval (CI): 18.15-56.01, p = 0.004]. After log₁₀-transformed HbEO transferred into a categorical variable based on the quintiles (Q1-Q5), the positive association remained in the highest group (Q5) compared to the lowest group (Q1) [β = 46.09, 95%CI: 12.29-79.90, p = 0.013]. Moreover, subgroup analysis demonstrated that the positive connection between log₁₀-transformed HbEO and TT was stronger in males than females.

Conclusion: The level of HbEO was positively related to TT in the U.S. population and the relation was more obvious in men compared to women.

Abstract Image

查看原文本刊更多论文

美国人口中环氧乙烷与睾酮之间的关系：基于 2013-2016 年全国健康与营养调查 (NHANES) 的横断面研究。

目的：环氧乙烷（EO）是一种普遍存在于环境中的工业污染物，与癌症和高血压等多种疾病有关。据我们所知，环氧乙烷与睾酮之间的关系尚未得到探讨。本文旨在评估美国人口中环氧乙烷与总睾酮（TT）之间的关系：本研究利用血红蛋白环氧乙烷（HbEO）水平来评估暴露于环氧乙烷的情况。本研究的数据来自 2013-2016 年美国国家健康与营养调查（NHANES）。共有3300名参与者参与了这项研究，并根据HbEO的五分位数分为5组。采用加权多变量逻辑回归评估 HbEO 与 TT 之间的关系。研究人员还进行了分组分析，以探讨不同分层中 HbEO 与 TT 之间的联系：结果：在完全调整模型中，经 log10 变形的 HbEO 与 TT 之间存在正相关关系[β = 37.08，95% 置信区间 (CI)：18.15-56.01，P = 0.004]。将 HbEO 对数 10 转换为基于五分位数（Q1-Q5）的分类变量后，与最低组（Q1）相比，最高组（Q5）的正相关性仍然存在 [β = 46.09，95% 置信区间（CI）：12.29-79.90，p = 0.013]。此外，亚组分析表明，经 log10 转换的 HbEO 与 TT 之间的正相关在男性中比在女性中更强：结论：在美国人群中，HbEO水平与TT呈正相关，男性与女性的关系更为明显。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Endocrine 医学-内分泌学与代谢

CiteScore

6.40

自引率

5.40%

发文量

期刊介绍： Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology. Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted. Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.