Strongyloides stercoralis infection in solid organ transplant recipients.

IF 3.6 3区医学 Q2 INFECTIOUS DISEASES

Current Opinion in Infectious Diseases Pub Date : 2024-10-01 Epub Date: 2024-08-02 DOI:10.1097/QCO.0000000000001046

John I Hogan, Sapna A Mehta

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引用次数: 0

Abstract

Purpose of review: Strongyloides stercoralis infection remains of concern due to its high associated morbidity among solid organ transplant recipients (SOTR) and the risk of donor-derived infection (DDI). We review key aspects of epidemiology to inform screening for and treatment of chronic infection among organ transplant candidates to reduce the risk of infectious complications in the posttransplant setting.

Recent findings: In this work, we offer guidance regarding the optimal management of Strongyloides hyperinfection syndrome and disseminated infection and offer recommendations regarding posttreatment surveillance and the potential need for repeat treatment during subsequent periods of augmented immunosuppression. This review also provides updated recommendations for screening of deceased and living donors as recently proposed by the Organ Procurement and Transplantation Network's Ad Hoc Disease Transmission Advisory Committee.

Summary: Risk reduction of Strongyloides infection in the SOTR population can be further enhanced by optimized treatment of infection, posttreatment surveillance during at-risk periods and recent proposed policy shifts to universal donor screening.

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实体器官移植受者中的盘尾丝菌感染。

综述目的：由于实体器官移植受者（SOTR）中的相关发病率较高，且存在供体源性感染（DDI）的风险，因此盘尾丝虫感染仍是一个令人担忧的问题。我们回顾了流行病学的主要方面，为器官移植候选者中慢性感染的筛查和治疗提供依据，以降低移植后感染并发症的风险：在这项工作中，我们为斯特龙线虫高感染综合征和播散性感染的最佳治疗提供了指导，并就治疗后监测以及在随后的增强免疫抑制期间重复治疗的潜在需求提出了建议。本综述还提供了器官获取与移植网络特设疾病传播咨询委员会（Ad Hoc Disease Transmission Advisory Committee）最近提出的关于筛查已故和在世捐献者的最新建议：通过对感染进行优化治疗、在高危期进行治疗后监测以及最近提出的对捐献者进行全面筛查的政策转变，可以进一步降低SOTR人群中感染斯特龙线虫的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Infectious Diseases 医学-传染病学

CiteScore

6.70

自引率

2.60%

发文量

121

审稿时长

6-12 weeks

期刊介绍： This reader-friendly, bimonthly resource provides a powerful, broad-based perspective on the most important advances from throughout the world literature. Featuring renowned guest editors and focusing exclusively on two topics, every issue of Current Opinion in Infectious Disease delivers unvarnished, expert assessments of developments from the previous year. Insightful editorials and on-the-mark invited reviews cover key subjects such as HIV infection and AIDS; skin and soft tissue infections; respiratory infections; paediatric and neonatal infections; gastrointestinal infections; tropical and travel-associated diseases; and antimicrobial agents.