Identification of HLA alleles involved in immune thrombotic thrombocytopenic purpura patients from Turkey.

IF 1.2 4区 医学 Q4 HEMATOLOGY
Blood Coagulation & Fibrinolysis Pub Date : 2024-09-01 Epub Date: 2024-07-24 DOI:10.1097/MBC.0000000000001318
Cevat İlteriş Kikili, Demet Kivanç, Damla Ortaboz, Hayriye Şentürk Çiftçi, Mustafa Murat Özbalak, Mustafa Nuri Yenerel, Meliha Nalçaci, Muhlis Cem Ar, Fatma Savran Oğuz, Sevgi Kalayoğlu Beşişik
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引用次数: 0

Abstract

Thrombotic thrombocytopenic purpura (TTP) is one of the rare group disorders classified as thrombotic microangiopathies (TMAs). Approximately 90% of TTP developed immune-mediation by the formation of antibodies against the enzyme ADAMTS-13. The exact cause is unknown. To establish an association between human leukocyte antigen (HLA) and autoimmune basis, as susceptibility or protection against the disease, we contributed a study aiming to evaluate the role of HLA in immune-mediated TTP (iTTP). Considering epidemiological factors such as age, sex, ethnicity, and geographical origins, we contributed the study in our country, Turkey, which consist of a very heterogeneous population. Patients' data collection was retrospectively from electronic database on two University hospitals having big therapeutic apheresis service. Control arm was healthy people registered as stem cell donors matched in terms of age and sex. The frequency of HLA-DRB1 and HLA-DQB1 alleles between acquired TTP and the control group was compared using the chi-square method. Yates correction and logistic regression were performed on these results. A total of 75 iTTP patients and 150 healthy individuals enrolled to the study. HLA-DRB1∗11, HLA-DQB1∗03, HLA-DRB1∗11:01, HLA-DRB1∗14:01, HLA-DRB1∗13:05, HLA-DRB1∗11 + HLA-DQB1∗03 allele pair and HLA-DRB1∗15 + HLA- DQB1∗06 were proved to be susceptibility allele pairs for iTTP. HLA-DRB1∗15, HLA-DRB1∗01:01, HLA-DRB1∗07:01, HLA-DRB1∗13:01, HLA-DRB1∗14:54, HLA-DQB1∗05:01, HLA-DQB1∗02:02 and HLA-DRB1∗07 + HLA-DQB1∗02 allele pair were found to be protective against iTTP. Our findings support an association with iTTP across very heterogenous populations in Turkey.

土耳其免疫性血栓性血小板减少性紫癜患者的 HLA 等位基因鉴定。
血栓性血小板减少性紫癜(TTP)是血栓性微血管病(TMA)中的一种罕见疾病。大约 90% 的 TTP 会通过形成针对 ADAMTS-13 酶的抗体而发生免疫介导。确切病因尚不清楚。为了建立人类白细胞抗原(HLA)与自身免疫基础之间的联系,并将其作为疾病的易感性或保护性,我们开展了一项研究,旨在评估 HLA 在免疫介导型 TTP(iTTP)中的作用。考虑到年龄、性别、种族和地理起源等流行病学因素,我们在我国土耳其开展了这项研究,该国的人口构成非常不均匀。患者数据的收集是通过两家拥有大型治疗性血液净化服务的大学医院的电子数据库进行的。对照组是年龄和性别匹配的健康干细胞捐献者。采用卡方方法比较了获得性TTP和对照组之间HLA-DRB1和HLA-DQB1等位基因的频率。对这些结果进行了耶茨校正和逻辑回归。共有 75 名 iTTP 患者和 150 名健康人参加了研究。HLA-DRB1∗11、HLA-DQB1∗03、HLA-DRB1∗11:01、HLA-DRB1∗14:01、HLA-DRB1∗13:05、HLA-DRB1∗11 + HLA-DQB1∗03等位基因对和HLA-DRB1∗15 + HLA- DQB1∗06被证明是iTTP的易感等位基因对。HLA-DRB1∗15、HLA-DRB1∗01:01、HLA-DRB1∗07:01、HLA-DRB1∗13:01、HLA-DRB1∗14:54、HLA-DQB1∗05:01、HLA-DQB1∗02:02 和 HLA-DRB1∗07 + HLA-DQB1∗02 等位基因对对 iTTP 具有保护作用。我们的研究结果表明,在土耳其非常不同的人群中,iTTP 与 HLA-DRB1∗07 和 HLA-DQB1∗02 等位基因对有保护作用。
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来源期刊
CiteScore
1.90
自引率
0.00%
发文量
111
审稿时长
4-8 weeks
期刊介绍: Blood Coagulation & Fibrinolysis is an international fully refereed journal that features review and original research articles on all clinical, laboratory and experimental aspects of haemostasis and thrombosis. The journal is devoted to publishing significant developments worldwide in the field of blood coagulation, fibrinolysis, thrombosis, platelets and the kininogen-kinin system, as well as dealing with those aspects of blood rheology relevant to haemostasis and the effects of drugs on haemostatic components
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