Expression of Concern: miR-145 sensitizes ovarian cancer cells to paclitaxel by targeting Sp1 and Cdk6

Abstract

Expression of Concern: X. Zhu, Y. Li, C. Xie, X. Yin, Y. Liu, Y. Cao, Y. Fang, X. Lin, Y. Xu, W. Xu, H. Shen, J. Wen, “ miR-145 sensitizes ovarian cancer cells to paclitaxel by targeting Sp1 and Cdk6,” International Journal of Cancer 135, no. 6 (2014): 1286–1296. https://doi.org/10.1002/ijc.28774.

This Expression of Concern is for the above article, published online on 08 February 2014, in Wiley Online Library (wileyonlinelibrary.com), and has been issued by agreement between the journal Editor-in-Chief, Prof. Christoph Plass; the Union for International Cancer Control; and John Wiley and Sons Ltd. The Expression of Concern has been agreed due to concerns raised by a third party regarding the similarity of blots between Figures 3j and 4a. The β-actin bands in Figure 3j for the cell line SKOV3/PTX appear similar to that in Figure 4a for the cell line A2780/PTX. The authors responded to an inquiry by the publisher, but were not able to supply original data or images. The journal is issuing this Expression of Concern because the results of the experiment as presented cannot be confirmed.