{"title":"Antimicrobial Activity of Anodic Porous Alumina with Controlled Surface Structures.","authors":"Takaaki Murata, Kumiko Yamaguchi, Takashi Yanagishita","doi":"10.1021/acs.langmuir.4c02202","DOIUrl":null,"url":null,"abstract":"<p><p>The antimicrobial properties of anodic porous alumina (APA) formed by the anodization of Al substrates were evaluated. APA surfaces with needle-like projections fabricated under controlled preparation conditions exhibited high antibacterial activity against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>. In antibacterial tests using APA with different interpore distances, all APA surfaces showed high antibacterial activity against <i>E. coli</i>, regardless of the interpore distance. In the case of <i>S. aureus</i>, in contrast, the smaller the interpore distance in APA is, the higher the antibacterial activity. These results indicate that different bacterial species require different optimal surface structures for antimicrobial activity. The needle-like projections formed on the surface of APA became finer as the interpore distance decreased; the finer the projections, the more efficiently the soft cell membrane of <i>S. aureus</i> is disrupted and the higher the antibacterial activity. On an APA with an interpore distance of 60 nm, the colony formation rate of <i>S. aureus</i> and <i>E. coli</i> was reduced to less than 1/100,000 compared to that of a nonanodized Al substrate. The fabrication process described in this article is expected to make it possible to impart antimicrobial properties to the surfaces of various Al products.</p>","PeriodicalId":50,"journal":{"name":"Langmuir","volume":null,"pages":null},"PeriodicalIF":3.7000,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Langmuir","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1021/acs.langmuir.4c02202","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/7/31 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
The antimicrobial properties of anodic porous alumina (APA) formed by the anodization of Al substrates were evaluated. APA surfaces with needle-like projections fabricated under controlled preparation conditions exhibited high antibacterial activity against Escherichia coli and Staphylococcus aureus. In antibacterial tests using APA with different interpore distances, all APA surfaces showed high antibacterial activity against E. coli, regardless of the interpore distance. In the case of S. aureus, in contrast, the smaller the interpore distance in APA is, the higher the antibacterial activity. These results indicate that different bacterial species require different optimal surface structures for antimicrobial activity. The needle-like projections formed on the surface of APA became finer as the interpore distance decreased; the finer the projections, the more efficiently the soft cell membrane of S. aureus is disrupted and the higher the antibacterial activity. On an APA with an interpore distance of 60 nm, the colony formation rate of S. aureus and E. coli was reduced to less than 1/100,000 compared to that of a nonanodized Al substrate. The fabrication process described in this article is expected to make it possible to impart antimicrobial properties to the surfaces of various Al products.
研究人员对铝基底阳极氧化形成的阳极多孔氧化铝(APA)的抗菌特性进行了评估。在受控制备条件下制成的具有针状突起的 APA 表面对大肠杆菌和金黄色葡萄球菌具有很高的抗菌活性。在使用不同孔间距的 APA 进行的抗菌测试中,无论孔间距如何,所有 APA 表面对大肠杆菌都表现出很高的抗菌活性。相反,对于金黄色葡萄球菌,APA 的孔间距越小,抗菌活性越高。这些结果表明,不同的细菌种类需要不同的最佳表面结构来获得抗菌活性。随着孔间距的减小,APA 表面形成的针状突起变得更细;突起越细,金黄色葡萄球菌的软细胞膜被破坏的效率越高,抗菌活性也越高。在孔间距为 60 nm 的 APA 上,金黄色葡萄球菌和大肠杆菌的菌落形成率与非阳极氧化铝基底相比降低到了 1/100,000 以下。本文所述的制造工艺有望为各种铝制品的表面赋予抗菌特性。
期刊介绍:
Langmuir is an interdisciplinary journal publishing articles in the following subject categories:
Colloids: surfactants and self-assembly, dispersions, emulsions, foams
Interfaces: adsorption, reactions, films, forces
Biological Interfaces: biocolloids, biomolecular and biomimetic materials
Materials: nano- and mesostructured materials, polymers, gels, liquid crystals
Electrochemistry: interfacial charge transfer, charge transport, electrocatalysis, electrokinetic phenomena, bioelectrochemistry
Devices and Applications: sensors, fluidics, patterning, catalysis, photonic crystals
However, when high-impact, original work is submitted that does not fit within the above categories, decisions to accept or decline such papers will be based on one criteria: What Would Irving Do?
Langmuir ranks #2 in citations out of 136 journals in the category of Physical Chemistry with 113,157 total citations. The journal received an Impact Factor of 4.384*.
This journal is also indexed in the categories of Materials Science (ranked #1) and Multidisciplinary Chemistry (ranked #5).