Association between encephalopathy and clinical outcomes of COVID-19: Findings from the Philippine CORONA Study

IF 2.9 4区医学 Q2 CLINICAL NEUROLOGY

Neurologia Pub Date : 2025-07-01 DOI:10.1016/j.nrl.2023.11.008

V.M.M. Anlacan , F.G.C. Gabriel , R.D.G. Jamora , E.Q. Villanueva III , M.C.C. Sy , M.H.L. Lee Yu , A.I. Espiritu

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Abstract

Introduction

This study aimed to determine whether encephalopathy is associated with such COVID-19 outcomes as disease severity, mortality, respiratory failure, intensive care unit (ICU) admission, duration of ventilator dependence, and length of ICU and hospital stay.

Methods

We performed a subgroup analysis comparing outcomes in patients with and without encephalopathy, based on data from a nationwide retrospective cohort study among adult patients hospitalized with COVID-19 at 37 hospital sites in the Philippines. The patient outcomes included for analysis were disease severity, mortality, respiratory failure, ICU admission, duration of ventilator dependence, and length of ICU and hospital stay.

Results

Of a total of 10 881 COVID-19 admissions, 622 patients had encephalopathy. The adjusted hazard ratios (aHR) for mortality among mild and severe cases were 9.26 and 1.63 times greater (P < .001), respectively, in the encephalopathy group compared to the no-encephalopathy group. Encephalopathy was associated with increased risk of severe COVID-19 (adjusted odds ratio [aOR]: 7.95; P < .001), respiratory failure (aHR: 5.40; P < .001), longer hospital stays (aOR: 1.36; P < .001), and admission to the ICU (aOR: 4.26; P < .001). We found no sufficient evidence that encephalopathy was associated with length of ICU stay (aOR: 1.11; P = .522) or duration of ventilator dependence (aOR: 0.88; P = .428).

Conclusions

Encephalopathy was associated with COVID-19 severity, mortality, respiratory failure, ICU admission, and longer hospital stays.

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COVID-19 脑病与临床结果之间的关系：菲律宾 CORONA 研究的结果

本研究旨在确定脑病是否与COVID-19结局相关，如疾病严重程度、死亡率、呼吸衰竭、重症监护病房（ICU）入院、呼吸机依赖持续时间、ICU和住院时间。方法：基于菲律宾37家医院的成人COVID-19住院患者的全国性回顾性队列研究数据，我们进行了亚组分析，比较了脑病患者和非脑病患者的结局。纳入分析的患者结局包括疾病严重程度、死亡率、呼吸衰竭、ICU入院、呼吸机依赖持续时间、ICU和住院时间。结果10881例新冠肺炎入院患者中，622例发生脑病。轻、重症病死率校正危险比分别为9.26倍和1.63倍(P <；.001)，脑病组与无脑病组比较，分别为。脑病与重症COVID-19风险增加相关(校正优势比[aOR]: 7.95；P & lt;.001)，呼吸衰竭(aHR: 5.40；P & lt;.001)，住院时间较长(aOR: 1.36；P & lt;.001)， ICU住院率(aOR: 4.26；P & lt;措施)。我们没有发现足够的证据表明脑病与ICU住院时间有关(aOR: 1.11；P = .522)或呼吸机依赖持续时间(aOR: 0.88；p = .428)。结论脑病与COVID-19严重程度、死亡率、呼吸衰竭、ICU入院率和住院时间相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurologia 医学-临床神经学

CiteScore

5.90

自引率

2.60%

发文量

135

审稿时长

48 days

期刊介绍： Neurología es la revista oficial de la Sociedad Española de Neurología y publica, desde 1986 contribuciones científicas en el campo de la neurología clínica y experimental. Los contenidos de Neurología abarcan desde la neuroepidemiología, la clínica neurológica, la gestión y asistencia neurológica y la terapéutica, a la investigación básica en neurociencias aplicada a la neurología. Las áreas temáticas de la revistas incluyen la neurologia infantil, la neuropsicología, la neurorehabilitación y la neurogeriatría. Los artículos publicados en Neurología siguen un proceso de revisión por doble ciego a fin de que los trabajos sean seleccionados atendiendo a su calidad, originalidad e interés y así estén sometidos a un proceso de mejora. El formato de artículos incluye Editoriales, Originales, Revisiones y Cartas al Editor, Neurología es el vehículo de información científica de reconocida calidad en profesionales interesados en la neurología que utilizan el español, como demuestra su inclusión en los más prestigiosos y selectivos índices bibliográficos del mundo.