{"title":"A functional interplay between non-coding RNAs and cancer-associated fibroblasts in breast cancer","authors":"Sara Anajafi , Razie Hadavi , Seyede Maryam Valizadeh-Otaghsara , Maryam Hemmati , Mahmoud Hassani , Samira Mohammadi-Yeganeh , Masoud Soleimani","doi":"10.1016/j.genrep.2024.101990","DOIUrl":null,"url":null,"abstract":"<div><p>Breast cancer is the most common cancer among women worldwide. Early detection and treatment are essential to improve patient outcomes and reduce mortality. Fibroblasts play a significant role in breast cancer development. Fibroblasts can be activated and influenced by cancer cells, leading to their identification as cancerassociated fibroblasts (CAFs), which are essential for tumor progression. In breast cancer, CAFs, as the main population of the tumor microenvironment, play a vital role and control several biological processes through non-coding RNAs(ncRNA) and signaling pathways. NcRNAs, such as long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), function as epigenetic regulators to control gene expression. Several studies have suggested that ncRNAs interfere in regulating tumor initiation and progression and can be used as biomarkers and therapeutic targets in different cancer types. Exosomes are extracellular vesicles that interact between fibroblasts and cancer cells. Exosomes derived from CAFs can influence breast cancer cells. Cancer cellderived exosomes may promote CAF phenotype, and CAF-derived exosomes transport miRNAs, lncRNAs, and several other substances, promoting breast cancer cell proliferation, migration, invasion, and angiogenesis, making them a potential therapeutic target. Despite little knowledge of the underlying functions of lncRNAs and miRNAs in CAFs, this review investigates how these ncRNAs cross-talk between tumor cells and CAFs.</p></div>","PeriodicalId":12673,"journal":{"name":"Gene Reports","volume":null,"pages":null},"PeriodicalIF":1.0000,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gene Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2452014424001134","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}
引用次数: 0
Abstract
Breast cancer is the most common cancer among women worldwide. Early detection and treatment are essential to improve patient outcomes and reduce mortality. Fibroblasts play a significant role in breast cancer development. Fibroblasts can be activated and influenced by cancer cells, leading to their identification as cancerassociated fibroblasts (CAFs), which are essential for tumor progression. In breast cancer, CAFs, as the main population of the tumor microenvironment, play a vital role and control several biological processes through non-coding RNAs(ncRNA) and signaling pathways. NcRNAs, such as long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), function as epigenetic regulators to control gene expression. Several studies have suggested that ncRNAs interfere in regulating tumor initiation and progression and can be used as biomarkers and therapeutic targets in different cancer types. Exosomes are extracellular vesicles that interact between fibroblasts and cancer cells. Exosomes derived from CAFs can influence breast cancer cells. Cancer cellderived exosomes may promote CAF phenotype, and CAF-derived exosomes transport miRNAs, lncRNAs, and several other substances, promoting breast cancer cell proliferation, migration, invasion, and angiogenesis, making them a potential therapeutic target. Despite little knowledge of the underlying functions of lncRNAs and miRNAs in CAFs, this review investigates how these ncRNAs cross-talk between tumor cells and CAFs.
Gene ReportsBiochemistry, Genetics and Molecular Biology-Genetics
CiteScore
3.30
自引率
7.70%
发文量
246
审稿时长
49 days
期刊介绍:
Gene Reports publishes papers that focus on the regulation, expression, function and evolution of genes in all biological contexts, including all prokaryotic and eukaryotic organisms, as well as viruses. Gene Reports strives to be a very diverse journal and topics in all fields will be considered for publication. Although not limited to the following, some general topics include: DNA Organization, Replication & Evolution -Focus on genomic DNA (chromosomal organization, comparative genomics, DNA replication, DNA repair, mobile DNA, mitochondrial DNA, chloroplast DNA). Expression & Function - Focus on functional RNAs (microRNAs, tRNAs, rRNAs, mRNA splicing, alternative polyadenylation) Regulation - Focus on processes that mediate gene-read out (epigenetics, chromatin, histone code, transcription, translation, protein degradation). Cell Signaling - Focus on mechanisms that control information flow into the nucleus to control gene expression (kinase and phosphatase pathways controlled by extra-cellular ligands, Wnt, Notch, TGFbeta/BMPs, FGFs, IGFs etc.) Profiling of gene expression and genetic variation - Focus on high throughput approaches (e.g., DeepSeq, ChIP-Seq, Affymetrix microarrays, proteomics) that define gene regulatory circuitry, molecular pathways and protein/protein networks. Genetics - Focus on development in model organisms (e.g., mouse, frog, fruit fly, worm), human genetic variation, population genetics, as well as agricultural and veterinary genetics. Molecular Pathology & Regenerative Medicine - Focus on the deregulation of molecular processes in human diseases and mechanisms supporting regeneration of tissues through pluripotent or multipotent stem cells.