Improved titanium-44 purification process for establishing a high apparent molar activity titanium-44/scandium-44 generator

IF 1.6 3区工程技术 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Applied Radiation and Isotopes Pub Date : 2024-07-20 DOI:10.1016/j.apradiso.2024.111451

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引用次数: 0

Abstract

⁴⁴Sc-radiopharmaceuticals are gaining more interest but still lack availability. The proof of principle of a⁴⁴Ti/⁴⁴Sc generator, which can produce ⁴⁴Sc daily, has been established but with some limitations and drawbacks. Despite recent advances, separation of ⁴⁴Ti from massive quantities of scandium target material is still cumbersome. In this work, the improved radiochemical separation of ⁴⁴Ti from residual scandium target material was carried out by precipitation of Sc with fluoride ions. Furthermore, two approaches were used to set up a high apparent molar activity small-scale generator. The first method relied on extraction chromatography for fine purification using a DGA resin, followed by loading of the purified ⁴⁴Ti onto a ZR resin column. In the second method, ⁴⁴Ti was loaded on the ZR resin directly after the precipitation step. This second method was used to set up a generator of 370 kBq and evaluate by radiolabeling. An apparent molar activity of 2 MBq/nmol was obtained for the radiolabeling with DOTA, the most common and suitable chelate for scandium. This result is comparable with previously published data on ⁴⁴ ^m/44Sc.

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用于建立高表观摩尔活性钛-44/钪-44 发生器的改进型钛-44 提纯工艺

44Sc 放射药物正受到越来越多的关注，但仍然缺乏供应。44Ti/44Sc 发生器的原理已经得到证实，可以每天产生 44Sc，但也存在一些局限性和缺点。尽管最近取得了一些进展，但从大量钪靶材料中分离 44Ti 仍然很麻烦。在这项工作中，通过氟离子沉淀钪，改进了从残余钪靶材料中分离 44Ti 的放射化学方法。此外，还采用两种方法建立了高表观摩尔活度小型发生器。第一种方法是使用 DGA 树脂通过萃取色谱法进行精细提纯，然后将提纯的 44Ti 装入 ZR 树脂柱。第二种方法是在沉淀步骤后直接将 44Ti 装入 ZR 树脂。第二种方法用于建立一个 370 kBq 的发生器，并通过放射性标记进行评估。用 DOTA（最常见和最合适的钪螯合物）进行放射性标记，得到的表观摩尔活度为 2 MBq/nmol。这一结果与之前公布的 44 m/44Sc 数据相当。

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来源期刊

Applied Radiation and Isotopes 工程技术-核科学技术

CiteScore

3.00

自引率

12.50%

发文量

406

审稿时长

13.5 months

期刊介绍： Applied Radiation and Isotopes provides a high quality medium for the publication of substantial, original and scientific and technological papers on the development and peaceful application of nuclear, radiation and radionuclide techniques in chemistry, physics, biochemistry, biology, medicine, security, engineering and in the earth, planetary and environmental sciences, all including dosimetry. Nuclear techniques are defined in the broadest sense and both experimental and theoretical papers are welcome. They include the development and use of α- and β-particles, X-rays and γ-rays, neutrons and other nuclear particles and radiations from all sources, including radionuclides, synchrotron sources, cyclotrons and reactors and from the natural environment. The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria. Papers dealing with radiation processing, i.e., where radiation is used to bring about a biological, chemical or physical change in a material, should be directed to our sister journal Radiation Physics and Chemistry.