Comparison of Microperimetry and Static Perimetry for Evaluating Macular Function and Progression in Retinitis Pigmentosa

IF 3.2 Q1 OPHTHALMOLOGY

Ophthalmology science Pub Date : 2024-07-20 DOI:10.1016/j.xops.2024.100582

Masatoshi Fukushima MD , Yan Tao MD , Sakurako Shimokawa MD , Huanyu Zhao MD , Shotaro Shimokawa MD, PhD , Jun Funatsu MD, PhD , Takahiro Hisai MD , Ayako Okita MD, PhD , Kohta Fujiwara MD, PhD , Toshio Hisatomi MD, PhD , Atsunobu Takeda MD, PhD , Yasuhiro Ikeda MD, PhD , Koh-Hei Sonoda MD, PhD , Yusuke Murakami MD, PhD

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Abstract

Purpose

To compare the usefulness of microperimetry and static automated perimetry in patients with retinitis pigmentosa (RP), using macular anatomical metrics as a reference.

Design

Prospective observational study.

Participants

Forty-eight eyes of 48 patients with RP in Kyushu University Hospital who underwent microperimetry-3 (MP-3) and Humphrey Field Analyzer (HFA) 10-2 testing ≥3 times during ≥2 years were included.

Methods

Macular anatomy (ellipsoid zone [EZ] length) was assessed by OCT, and macular function was assessed by MP-3 (mean retinal sensitivity at radii 2°, 4°, and 8°) and HFA10-2 program (mean retinal sensitivity at radii 2°, 4°, and 8°). Correlations between functional and anatomical parameters were analyzed cross sectionally at baseline and longitudinally by comparing the rate of progression.

Main Outcome Measures

Correlation coefficients between anatomical and functional metrics.

Results

The mean age at baseline was 50.1 ± 12.3 years, and the mean follow-up period was 2.8 ± 0.7 years. At baseline, EZ length was significantly correlated with MP-3 mean retinal sensitivity at radii 2°, 4°, and 8° (Spearman’s ρ = 0.65, 0.84, 0.89; all P < 0.005) and HFA10-2 mean retinal sensitivity at radii 2°, 4°, and 8° (Spearman’s ρ = 0.61, 0.73, 0.78; all P < 0.005). Longitudinal analysis showed that the slope of EZ length (−88.92 μm/year) was significantly correlated with the slope of MP-3 retinal sensitivity at 8° radius (−0.62 decibels [dB]/year; Spearman’s ρ = 0.31, P=0.03) and the slope of HFA retinal sensitivity at 8° radius (−0.60 dB/year; Spearman’s ρ = 0.43, P < 0.005).

Conclusions

Both MP-3 and HFA values were cross sectionally well-correlated with EZ length in patients with patients; however, these associations became weaker in the longitudinal analysis. This highlights the need for researchers to explore additional or more sensitive parameters to better monitor RP progression.

Financial Disclosure(s)

Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

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显微周边测量法与静态周边测量法在评估视网膜色素变性黄斑功能和进展方面的比较

目的以黄斑解剖指标为参考，比较显微视力测定法和静态自动视力测定法在视网膜色素变性（RP）患者中的实用性。方法收集九州大学医院 48 名 RP 患者的 48 只眼睛，这些患者在≥2 年的时间里接受了显微视力测定法-3（MP-3）和汉弗莱视野分析仪（HFA）10-2 测试≥3 次。方法通过 OCT 评估黄斑解剖结构（椭圆带 [EZ] 长度），通过 MP-3（半径为 2°、4° 和 8°时的平均视网膜灵敏度）和 HFA10-2 程序（半径为 2°、4° 和 8°时的平均视网膜灵敏度）评估黄斑功能。结果基线时的平均年龄为（50.1 ± 12.3）岁，平均随访时间为（2.8 ± 0.7）年。基线时，EZ 长度与半径为 2°、4° 和 8°的 MP-3 平均视网膜灵敏度显著相关（Spearman's ρ = 0.65、0.84、0.89；均为 P <；0.005），与半径为 2°、4° 和 8°的 HFA10-2 平均视网膜灵敏度显著相关（Spearman's ρ = 0.61、0.73、0.78；均为 P <；0.005）。纵向分析表明，EZ 长度的斜率（-88.92 μm/年）与半径为 8°的 MP-3 视网膜灵敏度的斜率（-0.62 分贝 [dB]/年；Spearman's ρ = 0.31，P=0.03）和半径为 8°的 HFA 视网膜灵敏度的斜率（-0.结论MP-3和HFA值在横断面上都与患者的EZ长度有很好的相关性；但是，在纵向分析中，这些相关性变弱了。这突出表明，研究人员需要探索更多或更敏感的参数，以更好地监测 RP 的进展。

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