Assessment of albendazole efficacy against Ascaris lumbricoides at three sites of Andhra Pradesh, Odisha, and Kerala in India

IF 1.9 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Vinay Garg, Ankur Garg, Shubha Garg, Sudhir Kumar Jain, T. Dikid, Saurabh Jain, Jitendra Manjhi, A. Montresor, Atul Goel
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引用次数: 0

Abstract

To assess efficacy of albendazole against Ascaris (A.) lumbrìcoides among school-children at three sites of Rajahmundry, Sundergarh and Wayanad. Sites were selected based on soil-transmitted helminths prevalence, different sociocultural-geographical characteristics and operational feasibility. 9-12 Years old children from 14 schools were included. The study was conducted in two rounds: baseline & follow up survey. All eligible children found positive for A. lumbricoides at baseline were administered supervised single tablet albendazole 400 mg under the National Deworming Day Initiative. During post-treatment follow-up survey, eligible children who provided second stool sample were included in the final analysis. Stool samples were examined using WHO recommended Kato-Katz technique. Efficacy was estimated based on cure rate (CR) and Fecal Egg Count Reduction Rate (FECRR) among children found positive in baseline and follow-up surveys. 328 Out of 625 (52.5%) were found positive for A. lumbricoides in the baseline survey and 85 out of 178 samples (47.8%) during post-treatment follow-up survey. Overall, the estimated CR was 52.2%. FECRR (95% CI) for albendazole was 72.6% (79.2%-66.0%). The FECRR was highest in East Godaveri [89.7% (96.8%-82.6%)], followed by Sundergarh [86.4% (95.3%-77.5%)] and Wayanad [69% (81.7%-56.4%)]. Our study confirmed overall reduction in FEC although with varying albendazole efficacy for A. lumbricoides infection at three different locations in India. However, these finding may be assessed in context of ongoing MDA under Filaria control program and further studies by in vivo as well as in vitro methods are required to reach to a conclusion on possible resistance if any.
在印度安得拉邦、奥迪沙和喀拉拉邦的三个地方评估阿苯达唑对蛔虫的药效
评估阿苯达唑对 Rajahmundry、Sundergarh 和 Wayanad 三个地区学龄儿童中蛔虫(A. lumbrìcoides)的疗效。 根据土壤传播蠕虫的流行情况、不同的社会文化和地理特征以及操作的可行性选择了这三个地点。研究对象包括 14 所学校的 9-12 岁儿童。研究分两轮进行:基线调查和后续调查。在 "全国驱虫日倡议 "下,所有在基线时发现蛔虫阳性的符合条件的儿童都接受了阿苯达唑单片 400 毫克的监督治疗。在治疗后的跟踪调查中,提供第二次粪便样本的合格儿童被纳入最终分析。粪便样本采用世界卫生组织推荐的卡托-卡茨(Kato-Katz)技术进行检验。根据基线调查和后续调查中发现的阳性儿童的治愈率(CR)和粪蛋计数减少率(FECRR)估算疗效。 在基线调查中,625 个样本中有 328 个(52.5%)对疟原虫呈阳性;在治疗后的跟踪调查中,178 个样本中有 85 个(47.8%)对疟原虫呈阳性。总体而言,估计 CR 为 52.2%。阿苯达唑的FECRR(95% CI)为72.6%(79.2%-66.0%)。东戈达韦里的 FECRR 最高[89.7%(96.8%-82.6%)],其次是桑德加尔[86.4%(95.3%-77.5%)]和威亚纳德[69%(81.7%-56.4%)]。 我们的研究证实,虽然阿苯达唑对印度三个不同地区的蛔虫感染有不同的疗效,但蛔虫感染率总体下降。不过,这些发现可以在丝虫控制计划下正在进行的 MDA 的背景下进行评估,并且需要通过体内和体外方法进行进一步研究,以便就可能存在的抗药性(如果有的话)得出结论。
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来源期刊
Asian Pacific journal of tropical medicine
Asian Pacific journal of tropical medicine PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-TROPICAL MEDICINE
CiteScore
4.00
自引率
9.70%
发文量
1936
审稿时长
3-8 weeks
期刊介绍: Asian Pacific Journal of Tropical Medicine (ISSN 1995-7645 CODEN: APJTB6), a publication of Editorial office of Hainan Medical University,is a peer-reviewed print + online Monthly journal. The journal''s full text is available online at http://www.apjtm.org/. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository. APJTM aims to provide an academic communicating platform for international physicians, medical scientists, allied health scientists and public health workers, especially those of the Asia-Pacific region and worldwide on tropical medicine, infectious diseases and public health, and to meet the growing challenges of understanding, preventing and controlling the dramatic global emergence and re-emergence of infectious diseases in the Asia-Pacific. The journal is proud to have an international and diverse editorial board that will assist and facilitate the publication of articles that reflect a global view on tropical medicine, infectious diseases and public health, as well as emphasizing our focus on supporting the needs of public health practitioners. The APJTM will allow us to seek opportunities to work with others who share our aim, and to enhance our work through partnership, and to uphold the standards of our profession and contribute to its advancement.
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