Recent developments in synthetic approaches for macromolecular prodrugs

IF 26 1区化学 Q1 POLYMER SCIENCE

Progress in Polymer Science Pub Date : 2024-08-01 DOI:10.1016/j.progpolymsci.2024.101855

Julien Alex , Christine Weber , Carlos Guerrero-Sanchez , Ulrich S. Schubert

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Abstract

In the last decades, nanoscale drug delivery systems have gained great attention partly due to their ability to improve the bioavailability of water insoluble drugs. To this end, the general aim in developing nanomedicine is to enhance efficacy, drug stability and drug safety profile ideally by an active- or passive-cell specific targeting effect. Alteration of dose-response and potential personalization might be future trademarks of nanomedicine. Macromolecular prodrugs (MPDs) represent a sub-class of polymer-drug conjugates featuring a degradable linkage between a macromolecule and a drug. MPDs are in particular interesting due to their capability to prolong blood circulation and to reduce side effects caused by minimized premature drug leakage. The maximum drug loading capacity is another advantage of MPDs over conventional nanomedicines. The chemical accessibility of drug conjugates and polymer carrier materials as well as recent developments in the MPD design of the last five years are summarized in this review article.

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大分子原药合成方法的最新进展

过去几十年来，纳米级给药系统获得了极大关注，部分原因是它们能够提高水溶性药物的生物利用度。为此，开发纳米药物的总体目标是通过主动或被动的细胞特异性靶向效应来提高药效、药物稳定性和药物安全性。改变剂量反应和潜在的个性化可能是纳米药物未来的标志。大分子原药（MPDs）是聚合物-药物共轭物的一个亚类，其特点是大分子与药物之间具有可降解的连接。大分子原药具有延长血液循环和减少药物过早渗漏所带来的副作用的功能，因此特别引人关注。与传统纳米药物相比，MPD 的另一个优势是具有最大的药物负载能力。本综述文章概述了药物共轭物和聚合物载体材料的化学可及性以及过去五年中 MPD 设计的最新进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Progress in Polymer Science 化学-高分子科学

CiteScore

48.70

自引率

1.10%

发文量

审稿时长

38 days

期刊介绍： Progress in Polymer Science is a journal that publishes state-of-the-art overview articles in the field of polymer science and engineering. These articles are written by internationally recognized authorities in the discipline, making it a valuable resource for staying up-to-date with the latest developments in this rapidly growing field. The journal serves as a link between original articles, innovations published in patents, and the most current knowledge of technology. It covers a wide range of topics within the traditional fields of polymer science, including chemistry, physics, and engineering involving polymers. Additionally, it explores interdisciplinary developing fields such as functional and specialty polymers, biomaterials, polymers in drug delivery, polymers in electronic applications, composites, conducting polymers, liquid crystalline materials, and the interphases between polymers and ceramics. The journal also highlights new fabrication techniques that are making significant contributions to the field. The subject areas covered by Progress in Polymer Science include biomaterials, materials chemistry, organic chemistry, polymers and plastics, surfaces, coatings and films, and nanotechnology. The journal is indexed and abstracted in various databases, including Materials Science Citation Index, Chemical Abstracts, Engineering Index, Current Contents, FIZ Karlsruhe, Scopus, and INSPEC.