Percutaneous LAAO and Pulsed-Field Isolation in a Canine Model

IF 8.4 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

JACC: Basic to Translational Science Pub Date : 2024-08-01 DOI:10.1016/j.jacbts.2024.05.008

引用次数: 0

Abstract

In this study, we investigated the feasibility, safety, and efficiency of using a novel device system to perform percutaneous left atrial appendage occlusion concomitant with left atrial appendage electrical isolation (LAAEI) via pulsed field ablation. In the acute phase, LAAEI was successful in 10 of 10 canines. At follow-up, full endothelialization was observed in 5 of 5 (100%) cases at 6 months. LAAEI was durable in 8 of 10 (80.00%) canines. Histologic examination in 4 of 6 LAAs with durable isolation showed transmural scars comprising fibrosis and fat. No pericardial effusion or phrenic paralysis was observed at follow-up. This preliminary study provides the scientific basis for first-in-human studies.

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经皮 LAAO 和脉冲场隔离在犬模型中的应用

在这项研究中，我们研究了使用新型设备系统在通过脉冲场消融术进行经皮左心房阑尾闭塞的同时进行左心房阑尾电隔离（LAAEI）的可行性、安全性和效率。在急性期，10 只犬中有 10 只成功进行了 LAAEI。随访 6 个月时，5 个病例中的 5 个（100%）观察到完全内皮化。10颗犬齿中有8颗（80.00%）的LAAEI效果持久。组织学检查显示，6 例 LAA 持久隔绝的病例中有 4 例出现了由纤维化和脂肪组成的跨膜疤痕。随访时未发现心包积液或膈肌麻痹。这项初步研究为首次人体研究提供了科学依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

JACC: Basic to Translational Science CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

14.20

自引率

1.00%

发文量

161

审稿时长

16 weeks

期刊介绍： JACC: Basic to Translational Science is an open access journal that is part of the renowned Journal of the American College of Cardiology (JACC). It focuses on advancing the field of Translational Cardiovascular Medicine and aims to accelerate the translation of new scientific discoveries into therapies that improve outcomes for patients with or at risk for Cardiovascular Disease. The journal covers thematic areas such as pre-clinical research, clinical trials, personalized medicine, novel drugs, devices, and biologics, proteomics, genomics, and metabolomics, as well as early phase clinical trial methodology.