Prevalencia y características clínico-epidemiológicas de la hepatitis crónica por el virus de la hepatitis delta en la isla de Gran Canaria

IF 2.6 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica Pub Date : 2024-11-01 DOI:10.1016/j.eimc.2024.06.008

Goretti Redondo Betancor , Melisa Hernández Febles , Raquel Zaragozá González , Rafael Granados Monzón , Ildefonso Quiñones Morales , Adolfo de Salazar , Federico García García , María José Pena López

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引用次数: 0

Abstract

Objective

The objective of this study was to know the prevalence and clinical-epidemiological characteristics of patients with chronic infection due to hepatitis D virus (HDV).

Patients and methods

A retrospective descriptive study was carried out on patients with HDV infection under follow-up in a hospital in 2023. All patients carrying HBsAg were tested for antibodies against HDV. HDV RNA detection was performed in all antibody-positive samples. The medical records were reviewed.

Results

Of the 340 patients carrying HBsAg, 24 (7.1%) had anti-HDV antibodies, and 6 (25%) had detectable HDV RNA (chronic infection). The prevalence of chronic hepatitis in HBsAg carriers was 1.8%. All patients had a genotype 1 infection. Half of the patients were of African origin and 29.2% were Spanish. Of the 6 patients with chronic infection, 5 (83.3%) had cirrhosis and 2 (33.3%) had hepatocellular carcinoma. Half of the patients had some exacerbation of the disease during follow-up. Of the 18 patients without viremia, 2 (11.1%) presented cirrhosis (one recently diagnosed). The mean follow-up time of patients without viremia was 13.5 years.

Conclusions

The prevalence of chronic HDV hepatitis in our area is low and in all cases it presents as an advanced disease, with exacerbations during follow-up. Patients without viremia have probably resolved the infection, as viremia was not detected in any moment.

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大加那利岛慢性乙型肝炎病毒性肝炎的发病率和临床流行病学特征。

本研究旨在了解丁型肝炎病毒（HDV）慢性感染患者的患病率和临床流行病学特征。患者和方法对 2023 年在一家医院接受随访的 HDV 感染患者进行了回顾性描述性研究。对所有携带 HBsAg 的患者进行了 HDV 抗体检测。对所有抗体阳性样本进行了 HDV RNA 检测。结果在 340 名携带 HBsAg 的患者中，24 人（7.1%）有抗 HDV 抗体，6 人（25%）检测到 HDV RNA（慢性感染）。HBsAg 携带者中慢性肝炎的发病率为 1.8%。所有患者均为基因型 1 感染。半数患者为非洲裔，29.2%为西班牙裔。在 6 名慢性感染患者中，5 人（83.3%）患有肝硬化，2 人（33.3%）患有肝细胞癌。半数患者在随访期间病情有所加重。在 18 名无病毒感染的患者中，有 2 人（11.1%）患有肝硬化（其中一人最近确诊）。无病毒血症患者的平均随访时间为 13.5 年。结论慢性 HDV 肝炎在我们地区的发病率较低，所有病例均为晚期，随访期间病情加重。没有病毒血症的患者很可能已经摆脱了感染，因为在任何时候都没有检测到病毒血症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Enfermedades infecciosas y microbiologia clinica 医学-传染病学

CiteScore

2.10

自引率

8.00%

发文量

194

审稿时长

29 days

期刊介绍： Hoy está universalmente reconocida la renovada y creciente importancia de la patología infecciosa: aparición de nuevos agentes patógenos, de cepas resistentes, de procesos con expresión clínica hasta ahora desconocida, de cuadros de una gran complejidad. Paralelamente, la Microbiología y la Infectología Clínicas han experimentado un gran desarrollo como respuesta al reto planteado por la actual patología infecciosa. Enfermedades Infecciosas y Microbiología Clínica es la Publicación Oficial de la Sociedad Española SEIMC. Cumple con la garantía científica de esta Sociedad, la doble función de difundir trabajos de investigación, tanto clínicos como microbiológicos, referidos a la patología infecciosa, y contribuye a la formación continuada de los interesados en aquella patología mediante artículos orientados a ese fin y elaborados por autores de la mayor calificación invitados por la revista.