Prevalence of hypogonadism in men with and without chronic obstructive pulmonary disease: A cross-sectional study

4区医学 Q3 Nursing

Endocrinologia, Diabetes y Nutricion Pub Date : 2024-10-01 DOI:10.1016/j.endinu.2024.05.010

Horacio Matías Castro , Pablo Knoblovits , Joaquin Maritano Furcada , Eduardo Luis De Vito , Sebastían Matias Suarez , Pablo Rene Costanzo

{"title":"Prevalence of hypogonadism in men with and without chronic obstructive pulmonary disease: A cross-sectional study","authors":"Horacio Matías Castro , Pablo Knoblovits , Joaquin Maritano Furcada , Eduardo Luis De Vito , Sebastían Matias Suarez , Pablo Rene Costanzo","doi":"10.1016/j.endinu.2024.05.010","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Hypogonadism is a common finding of chronic obstructive pulmonary disease (COPD). However, the prevalence of hypogonadism in COPD varies among studies. The aim of this study was to determine and compare the prevalence of hypogonadism in men with and without COPD.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional study with 134 patients with stable COPD and 70 age-matched men with non-COPD. Hypogonadism was defined by the presence of symptoms according to the Androgen Deficiency in Aging Males questionnaire, along with total testosterone deficiency (<300ng/dL).</div></div><div><h3>Results</h3><div>Patients had a mean age of 68 years (SD, 6), a body mass index of 28kg/m<sup>2</sup> (SD, 6), and 17% were current smokers. The prevalence of hypogonadism was 41.8% in COPD men (<em>N</em>  =7, 95%CI, 4–20), with a prevalence ratio of 4.2 (95%CI, 2.0–8.7, <em>p</em>   =<0.001). In the COPD group, 89.3% of patients had hypogonadotropic hypogonadism and 10.7%, hypergonadotropic hypogonadism. The prevalence of hypogonadism was higher in severe vs non-severe COPD patients (55.8% vs 35.2%; <em>p</em>  <!-->0.024).</div></div><div><h3>Conclusions</h3><div>The prevalence of hypogonadism was high and greater in COPD vs non-COPD men. This study suggests that COPD patients should be screened for hypogonadism.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"71 8","pages":"Pages 348-354"},"PeriodicalIF":0.0000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endocrinologia, Diabetes y Nutricion","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2530016424001241","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Nursing","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Hypogonadism is a common finding of chronic obstructive pulmonary disease (COPD). However, the prevalence of hypogonadism in COPD varies among studies. The aim of this study was to determine and compare the prevalence of hypogonadism in men with and without COPD.

Methods

We conducted a cross-sectional study with 134 patients with stable COPD and 70 age-matched men with non-COPD. Hypogonadism was defined by the presence of symptoms according to the Androgen Deficiency in Aging Males questionnaire, along with total testosterone deficiency (<300 ng/dL).

Results

Patients had a mean age of 68 years (SD, 6), a body mass index of 28 kg/m² (SD, 6), and 17% were current smokers. The prevalence of hypogonadism was 41.8% in COPD men (N = 56, 95%CI, 33–51) and 10.0% in non-COPD men (N = 7, 95%CI, 4–20), with a prevalence ratio of 4.2 (95%CI, 2.0–8.7, p < 0.001). The prevalence of low total testosterone concentrations (<300 ng/dL) were significantly higher in COPD patients vs the control group (47.0% vs 15.7%, p = <0.001). In the COPD group, 89.3% of patients had hypogonadotropic hypogonadism and 10.7%, hypergonadotropic hypogonadism. The prevalence of hypogonadism was higher in severe vs non-severe COPD patients (55.8% vs 35.2%; p = 0.024).

Conclusions

The prevalence of hypogonadism was high and greater in COPD vs non-COPD men. This study suggests that COPD patients should be screened for hypogonadism.

查看原文本刊更多论文

患有和未患有慢性阻塞性肺病的男性性腺功能减退症的患病率：横断面研究

背景性腺功能减退症是慢性阻塞性肺病（COPD）的常见病因。然而，慢性阻塞性肺病患者性腺功能减退症的发病率在不同研究中存在差异。本研究的目的是确定并比较慢性阻塞性肺病男性和非慢性阻塞性肺病男性性腺功能减退症的患病率。方法我们对 134 名稳定期慢性阻塞性肺病患者和 70 名年龄匹配的非慢性阻塞性肺病男性进行了横断面研究。结果患者的平均年龄为 68 岁（SD，6），体重指数为 28 kg/m2（SD，6），17% 的患者目前吸烟。慢性阻塞性肺病男性的性腺功能减退症患病率为41.8%（N = 56，95%CI，33-51），非慢性阻塞性肺病男性的患病率为10.0%（N = 7，95%CI，4-20），患病率比为4.2（95%CI，2.0-8.7，p <0.001）。与对照组相比，慢性阻塞性肺病患者总睾酮浓度低（300 ng/dL）的患病率明显更高（47.0% vs 15.7%，p = 0.001）。在 COPD 组中，89.3% 的患者患有性腺功能减退症，10.7% 的患者患有高性腺功能减退症。严重慢性阻塞性肺病患者与非严重慢性阻塞性肺病患者相比，性腺功能减退症的患病率更高（55.8% vs 35.2%; p = 0.024）。这项研究表明，慢性阻塞性肺病患者应接受性腺功能减退症筛查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Endocrinologia, Diabetes y Nutricion Nursing-Nutrition and Dietetics

CiteScore

2.10

自引率

0.00%

发文量

169

审稿时长

35 days

期刊介绍： Endocrinología, Diabetes y Nutrición is the official journal of the Spanish Society of Endocrinology and Nutrition (Sociedad Española de Endocrinología y Nutrición, SEEN) and the Spanish Society of Diabetes (Sociedad Española de Diabetes, SED), and was founded in 1954. The aim of the journal is to improve knowledge and be a useful tool in practice for clinical and laboratory specialists, trainee physicians, researchers, and nurses interested in endocrinology, diabetes, nutrition and related disciplines. It is an international journal published in Spanish (print and online) and English (online), covering different fields of endocrinology and metabolism, including diabetes, obesity, and nutrition disorders, as well as the most relevant research produced mainly in Spanish language territories. The quality of the contents is ensured by a prestigious national and international board, and by a selected panel of specialists involved in a rigorous peer review. The result is that only manuscripts containing high quality research and with utmost interest for clinicians and professionals related in the field are published. The Journal publishes Original clinical and research articles, Reviews, Special articles, Clinical Guidelines, Position Statements from both societies and Letters to the editor. Endocrinología, Diabetes y Nutrición can be found at Science Citation Index Expanded, Medline/PubMed and SCOPUS.