Relationship between calcium-to-magnesium ratio and malaria parasite density among children with uncomplicated malaria infection

Oziegbe Johnson Airen, Loveth Amenaghawon Emokpae, Zainab Omoruyi, Mathias Abiodun Emokpae
{"title":"Relationship between calcium-to-magnesium ratio and malaria parasite density among children with uncomplicated malaria infection","authors":"Oziegbe Johnson Airen, Loveth Amenaghawon Emokpae, Zainab Omoruyi, Mathias Abiodun Emokpae","doi":"10.4314/ahs.v24i2.18","DOIUrl":null,"url":null,"abstract":"Background/Objective: A high calcium-to-magnesium ratio above 2:1 has been associated with higher risk of metabolic, inflammation and cardiovascular disorders. This study evaluates the serum levels of iron, magnesium, calcium, folate, vitamin B12 and calcium to magnesium ratio in children with uncomplicated malaria infection. \nMaterials and Methods: Measured nutritional parameters were determined in 300 children (100 males and 100 females) with malaria infection and 100 children (50 males and 50 females) without malaria infection using Enzyme linked Immunosorbent Assay and spectrophotometric methods. \nResults: Significantly lower (p<0.001) levels of serum magnesium, iron, vitamin B12, folate and Packed cell volume (p<0.03) were observed among children with malaria than controls. On the other hand, serum calcium (8.45±0.20) and calcium-to-magnesium ratio (3.9:1.0) (were significantly higher (p<0.001) in malaria infected children than controls. Calcium to magnesium ratio correlated (r=0.188; p<0.01) with malaria parasitaemia. \nConclusion: Higher serum calcium-to-magnesium ratio above the recommended 2.1 may contribute to increase risk of morbidity and mortality. Nutritional intervention aimed at lowering the ca/mg ratio may be essential in the management of malaria infection in Children. \nKeywords: Child; calcium; magnesium; parasites.","PeriodicalId":94295,"journal":{"name":"African health sciences","volume":"117 6","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"African health sciences","FirstCategoryId":"0","ListUrlMain":"https://doi.org/10.4314/ahs.v24i2.18","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Background/Objective: A high calcium-to-magnesium ratio above 2:1 has been associated with higher risk of metabolic, inflammation and cardiovascular disorders. This study evaluates the serum levels of iron, magnesium, calcium, folate, vitamin B12 and calcium to magnesium ratio in children with uncomplicated malaria infection. Materials and Methods: Measured nutritional parameters were determined in 300 children (100 males and 100 females) with malaria infection and 100 children (50 males and 50 females) without malaria infection using Enzyme linked Immunosorbent Assay and spectrophotometric methods. Results: Significantly lower (p<0.001) levels of serum magnesium, iron, vitamin B12, folate and Packed cell volume (p<0.03) were observed among children with malaria than controls. On the other hand, serum calcium (8.45±0.20) and calcium-to-magnesium ratio (3.9:1.0) (were significantly higher (p<0.001) in malaria infected children than controls. Calcium to magnesium ratio correlated (r=0.188; p<0.01) with malaria parasitaemia. Conclusion: Higher serum calcium-to-magnesium ratio above the recommended 2.1 may contribute to increase risk of morbidity and mortality. Nutritional intervention aimed at lowering the ca/mg ratio may be essential in the management of malaria infection in Children. Keywords: Child; calcium; magnesium; parasites.
无并发症疟疾感染儿童的钙镁比值与疟原虫密度之间的关系
背景/目的:钙镁比高于 2:1 会增加患代谢、炎症和心血管疾病的风险。本研究评估了无并发症疟疾感染儿童血清中铁、镁、钙、叶酸、维生素 B12 的水平以及钙镁比值。材料和方法:使用酶联免疫吸附试验和分光光度法测定 300 名感染疟疾的儿童(100 名男性和 100 名女性)和 100 名未感染疟疾的儿童(50 名男性和 50 名女性)的营养参数。结果显示与对照组相比,疟疾患儿的血清镁、铁、维生素 B12、叶酸和包细胞容积水平明显较低(p<0.001)。另一方面,疟疾感染儿童的血清钙(8.45±0.20)和钙镁比(3.9:1.0)明显高于对照组(P<0.001)。钙镁比值与疟疾寄生虫血症相关(r=0.188;p<0.01)。结论血清钙镁比高于建议的 2.1,可能会增加发病和死亡风险。旨在降低钙镁比值的营养干预可能是治疗儿童疟疾感染的关键。关键词儿童;钙;镁;寄生虫。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信