Synthesis, evaluation, and structural characterization of antioxidant diorganotin(IV) Complexes derived from ampicillin: a comprehensive study

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-07-12 DOI:10.4314/bcse.v38i5.8

Rafid Ryyis Arraq, Hadeer Jasem, Angham G. Hadi

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Abstract

This study offerings the preparation, structural analysis, and estimation of novel diorganotin(IV) complexes derived from an ampicillin as a ligand in terms of their antioxidant activity. The diorganotin complexes were yielded by a direct reaction between ampicillin and a different number of diorganotin(IV) chloride precursors. Various spectroscopic techniques, including CHNS, FTIR and nuclear magnetic resonance (1H, 13C, 119Sn NMR), were used to explain the molecular structures of the produced complexes. Through in vitro experiments such as the CUPRAC and DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenging technique, the novel diorganotin complexes' antioxidant activity were assessed. The results were compared to that of ligand antioxidants to evaluate the effectiveness of the complexes that were produced. The structural properties of the complexes were linked to their antioxidant capacity to identify the connection between molecular structure and biological function. KEY WORDS: Ampicillin, DPPH method, Diorganotin(IV) complexes, Antioxidants Bull. Chem. Soc. Ethiop. 2024, 38(5), 1291-1300. DOI: https://dx.doi.org/10.4314/bcse.v38i5.8

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源自氨苄西林的抗氧化剂二甘锡（IV）络合物的合成、评估和结构特征：一项综合研究

本研究提供了以氨苄西林为配体的新型二甘锡（IV）复合物的制备、结构分析和抗氧化活性评估。这些二甘锡配合物是由氨苄西林和不同数量的二甘锡（IV）氯化物前体直接反应生成的。为了解释所生成复合物的分子结构，研究人员使用了多种光谱技术，包括氯离子显微镜、傅立叶变换红外光谱和核磁共振（1H、13C、119Sn NMR）。通过 CUPRAC 和 DPPH（2,2-二苯基-1-苦基肼）自由基清除技术等体外实验，评估了新型二甘醇锡复合物的抗氧化活性。将结果与配体抗氧化剂的结果进行了比较，以评估所制得的配合物的有效性。将复合物的结构特性与其抗氧化能力联系起来，以确定分子结构与生物功能之间的联系。关键词：氨苄西林、DPPH 法、Diorganotin(IV) 复合物、抗氧化剂 Bull.Chem.Soc.2024, 38(5), 1291-1300. DOI: https://dx.doi.org/10.4314/bcse.v38i5.8

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.