Advancements in Natural Alkaloid-Loaded Drug Delivery Systems for Enhanced Peptic Ulcer Treatment: A Review

IF 0.3 Q4 PHARMACOLOGY & PHARMACY

Current Drug Therapy Pub Date : 2024-07-19 DOI:10.2174/0115748855312609240628110440

Nagma Shahin, Parag Jain, Ajazuddin, K. Nagori

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Abstract

Peptic ulcers, which damage the gastrointestinal tract lining, are a significant global health issue. The traditional approaches to treating peptic ulcers have poor bioavailability, unstable formulations, and undesirable side effects. Natural alkaloids have garnered increased interest as potential therapeutic agents in recent years due to their diverse pharmacological actions and decreased toxicity profiles. This manuscript summarizes recent progress in natural alkaloids for peptic ulcer treatment, highlighting new drug delivery methods. Natural alkaloids, originating from different plants, have anti-inflammatory, antioxidant, and antibacterial properties, potentially accelerating the healing of peptic ulcers. Moreover, medicines don't always function properly because they degrade too fast, don't dissolve well, and have other problems, such as insufficient bioavailability. Creative liposome delivery systems, microspheres, nanocarriers, and other customized delivery strategies have shown promise in overcoming these barriers. By distributing the medication gradually and precisely, these innovative techniques improve the medication and effectiveness at the ulcer site. As a result, natural ingredients work better and provide better treatment results.

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用于加强消化性溃疡治疗的天然生物碱载药系统的研究进展：综述

消化性溃疡会损伤胃肠道黏膜，是一个重要的全球性健康问题。治疗消化性溃疡的传统方法生物利用度低、制剂不稳定、副作用大。近年来，天然生物碱作为潜在的治疗药物受到越来越多的关注，因为它们具有多种药理作用，而且毒性较低。本手稿总结了天然生物碱治疗消化性溃疡的最新进展，重点介绍了新的给药方法。源自不同植物的天然生物碱具有抗炎、抗氧化和抗菌特性，有可能加速消化性溃疡的愈合。此外，由于药物降解过快、溶解性差以及生物利用度不足等其他问题，药物并不总能发挥正常作用。创造性的脂质体给药系统、微球、纳米载体和其他定制给药策略有望克服这些障碍。通过逐步精确地分配药物，这些创新技术改善了溃疡部位的药物和疗效。因此，天然成分能更好地发挥作用，提供更好的治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Drug Therapy PHARMACOLOGY & PHARMACY-

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： Current Drug Therapy publishes frontier reviews of high quality on all the latest advances in drug therapy covering: new and existing drugs, therapies and medical devices. The journal is essential reading for all researchers and clinicians involved in drug therapy.