Magnetic Substrates for Tissue Engineering—A Review

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-07-24 DOI:10.3390/magnetochemistry10080052

T. Błachowicz, Andrea Ehrmann

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引用次数: 0

Abstract

Tissue engineering is based on combining cells with suitable scaffolds and growth factors. Recently, bone tissue engineering has been especially investigated deeply due to a large number of bone-related diseases. One approach to improve scaffolds is based on using piezoelectric materials as a way to influence the growing bone tissue by mechanical stress. Another method to stimulate tissue growth is by applying an external magnetic field to composites of magnetostrictive and piezoelectric materials, as well as the possibility to prepare oriented surfaces by orienting embedded magnetic fibers or nanoparticles. In addition, magnetic scaffolds without other special properties have also been reported to show improved properties for bone tissue and other tissue engineering. Here, we provide an overview of recent research on magnetic scaffolds for tissue engineering, differentiating between bone and other tissue engineering. We show the advantages of magnetic scaffolds, especially related to cell guidance and differentiation, and report recent progress in the production and application of such magnetic substrates for different areas of tissue engineering.

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用于组织工程的磁性基底--综述

组织工程学的基础是将细胞与合适的支架和生长因子相结合。最近，由于大量与骨骼有关的疾病，骨组织工程尤其受到深入研究。一种改进支架的方法是使用压电材料，通过机械应力影响生长中的骨组织。另一种刺激组织生长的方法是向磁致伸缩材料和压电材料的复合材料施加外部磁场，以及通过定向嵌入的磁性纤维或纳米粒子来制备定向表面。此外，据报道，不具有其他特殊性质的磁性支架也能改善骨组织和其他组织工程的性能。在此，我们概述了近期用于组织工程的磁性支架研究，并对骨组织工程和其他组织工程进行了区分。我们展示了磁性支架的优势，尤其是与细胞引导和分化相关的优势，并报告了在生产和应用此类磁性基底用于不同组织工程领域方面的最新进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.