Research question: A comparison of Fluorouracil and Docetaxel in the treatment of gastric cancer

Abstract

Cancer is a serious lethal disease that is prevalent worldwide. This disease is mainly due to the development of abnormal cells that divide without any control. These abnormal cells, also known as tumor cells, can destroy normal body tissue. Causing numerous deaths around the world. Gastric cancer, commonly known as stomach cancer, is the cancer to be discussed in depth in this essay. It is one of the most prevalent and lethal cancers worldwide. Its cases and mortality rates vary significantly across different regions, reflecting differences in diet, genetics, and medicine access. Gastric cancer presents substantial challenges in medical treatment. The disease's complexity also leads to the exploration of various treatment methods. Among many pharmacological options, Fluorouracil and Docetaxel are two significant medicines that are worth discussing in depth. Fluorouracil and Docetaxel are both used in chemotherapy. However, they have distinct mechanisms and properties. Fluorouracil is a pyrimidine analog used to inhibit DNA synthesis of cancerous cells, while Docetaxel is a taxane that targets microtubules. They all played a vital role in treating cancer. Nevertheless, their comparative effectiveness and safety remain in debate. This essay aims to provide a depth comparison of Fluorouracil and Docetaxel. Focusing on their chemical structure, mechanisms of action, delivery modes, resistance, and toxicity, in the treatment of gastric cancer. Offering a better comprehension of two drugs, which are used for their optimal use in patient care.