The mechanism of MRSA drug tolerance and the comparison between vancomycin and daptomycin in the treatment of MRSA infections

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is a superbug that is resistant to multiple antibiotics commonly used in medication and has caused severe infections in humans for hundreds of years. This review examines the MRSA drug resistance mechanism and compares the efficacies between two antibiotics, daptomycin and vancomycin, in treating MRSA infections. The resistance mechanism of MRSA alters the structure of inactivating the antibiotics. Therefore, the MRSA resistance to daptomycin and vancomycin is analyzed to show how MRSA reacts to different antibiotics preferred in therapy. Moreover, the efficacies of two antimicrobial drugs were analyzed by the research and data from journals and magazines. Combined with rifampin, two antibiotics show more potent efficacies with fewer doses, and could be an alternative therapy to conventional individual antibiotics only.