Jatropha tanjorensis leaf extracts attenuate adrenaline-induced myocardial cell injury via modulation of cardio-inflammatory biomarkers in Wistar rats

Abstract

Myocardial injury (MI) has remain a global concern due to high mortality rate associated with cardiovascular diseases. Jatropha tanjorensis (J. tanjorensis) is a medicinal herb with proven medicinal properties. This study investigated the level of cardio-inflammatory response in adrenaline-induced MI in rats treated with J. tanjorensis. Twenty Wistar rats were randomly divided into four groups (n = 5). Group 1 served as Control. Group 2 was induced with MI using 2 mg/kg bodyweight of adrenaline administered subcutaneously for two days at 24 h interval between the first and second administrations. Group 3 received 200 mg/kg body weight of methanol extract of J. tanjorensis orally for 14days while Group 4 were induced with MI using 2 mg/kg body weight of adrenaline and treated with 200 mg/kg of J. tanjorensis leaf extract for 14 days. Blood was collected via cardiac puncture for biochemical analysis. J. tanjorensis reduced adrenaline-induced MI by lowering serum concentration of ALT, AST and ALP, pro-inflammatory (MDA, CRP and IL-6) and cardiac injury markers (CK-MB, Troponin-I). SOD and NO level were also raised in J. tanjorensis-treated animals. The extract also restored histoarchitectural changes in the cardiac muscle. Jatropha tanjorensis mitigates cardio-inflammatory response and restores cyto-architecture of the cardiac muscle in adrenaline-induced MI rats.