Noradrenergic alterations associated with early life stress

IF 7.5 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews Pub Date : 2024-07-29 DOI:10.1016/j.neubiorev.2024.105832

Megan Sheppard , Jalil Rasgado-Toledo , Niall Duncan , Rebecca Elliott , Eduardo A. Garza-Villarreal , Nils Muhlert

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引用次数: 0

Abstract

Significant stress in childhood or adolescence is linked to both structural and functional changes in the brain in human and analogous animal models. In addition, neuromodulators, such as noradrenaline (NA), show life-long alterations in response to these early life stressors, which may impact upon the sensitivity and time course of key adrenergic activities, such as rapid autonomic stress responses (the ‘fight or flight response’). The locus-coeruleus noradrenergic (LC-NA) network, a key stress-responsive network in the brain, displays numerous changes in response to significant early- life stress. Here, we review the relationship between NA and the neurobiological changes associated with early life stress and set out future lines of research that can illuminate how brain circuits and circulating neurotransmitters adapt in response to childhood stressors

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与早期生活压力有关的去甲肾上腺素能改变

在人类和类似的动物模型中，童年或青春期的重大压力与大脑结构和功能的变化有关。此外，神经调节剂，如去甲肾上腺素（NA），会因早期的生活压力而发生终生改变，这可能会影响关键肾上腺素能活动的敏感性和时间进程，如快速自主压力反应（"战斗或逃跑反应"）。脑室-小脑去甲肾上腺素能（LC-NA）网络是大脑中一个关键的应激反应网络，它在早期生活的重大应激反应中显示出许多变化。在此，我们回顾了去甲肾上腺素能与早期生活压力相关的神经生物学变化之间的关系，并提出了未来的研究方向，以阐明大脑回路和循环神经递质是如何适应童年压力的。

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来源期刊

Neuroscience and Biobehavioral Reviews 医学-行为科学

CiteScore

14.20

自引率

3.70%

发文量

466

审稿时长

6 months

期刊介绍： The official journal of the International Behavioral Neuroscience Society publishes original and significant review articles that explore the intersection between neuroscience and the study of psychological processes and behavior. The journal also welcomes articles that primarily focus on psychological processes and behavior, as long as they have relevance to one or more areas of neuroscience.