Gabriele Giua , Benjamin Strauss , Olivier Lassalle , Pascale Chavis , Olivier J. Manzoni
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引用次数: 0
Abstract
Fragile X Syndrome (FXS) stands out as a prominent cause of inherited intellectual disability and a prevalent disorder closely linked to autism. FXS is characterized by substantial alterations in social behavior, encompassing social withdrawal, avoidance of eye contact, heightened social anxiety, increased arousal levels, language deficits, and challenges in regulating emotions. Conventional behavioral assessments primarily focus on short-term interactions within controlled settings. In this study, we conducted a comprehensive examination of the adaptive group behavior of Fmr1 KO male mice over a three-day period, without introducing experimental interventions or task-based evaluations. The data unveiled intricate behavioral anomalies, with the most significant changes manifesting during the initial adaptation to unfamiliar environments. Notably, certain behaviors exhibited a gradual return to typical patterns over time. This dynamic Fmr1 KO phenotype exhibited heightened activity, featuring increased exploration, amplified social interest, and an unconventional approach to social interactions characterized by a higher frequency of shorter engagements. These findings contribute to the growing understanding of social behavior in individuals with FXS and underscore the significance of comprehending their adaptive responses in various environmental contexts.
脆性 X 综合征(FXS)是遗传性智力障碍的主要病因,也是一种与自闭症密切相关的常见疾病。脆性 X 综合征的特点是社交行为发生重大改变,包括社交退缩、避免目光接触、社交焦虑加重、唤醒水平升高、语言障碍以及情绪调节方面的挑战。传统的行为评估主要侧重于受控环境下的短期互动。在这项研究中,我们对 Fmr1 KO 雄性小鼠为期三天的适应性群体行为进行了全面检查,而没有引入实验干预或基于任务的评估。数据揭示了错综复杂的行为异常,其中最显著的变化体现在最初适应陌生环境的过程中。值得注意的是,某些行为会随着时间的推移逐渐恢复到典型模式。这种动态的 Fmr1 KO 表型表现出更强的活动性,其特点是探索性增强、社交兴趣扩大以及以更高频率的较短接触为特征的非传统社交互动方式。这些发现有助于人们进一步了解 FXS 患者的社会行为,并强调了理解他们在各种环境背景下的适应性反应的重要性。
期刊介绍:
Progress in Neuro-Psychopharmacology & Biological Psychiatry is an international and multidisciplinary journal which aims to ensure the rapid publication of authoritative reviews and research papers dealing with experimental and clinical aspects of neuro-psychopharmacology and biological psychiatry. Issues of the journal are regularly devoted wholly in or in part to a topical subject.
Progress in Neuro-Psychopharmacology & Biological Psychiatry does not publish work on the actions of biological extracts unless the pharmacological active molecular substrate and/or specific receptor binding properties of the extract compounds are elucidated.