Investigation of the causal relationship between breast cancer and thyroid cancer: a set of two-sample bidirectional Mendelian randomization study.

IF 3 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Endocrine Pub Date : 2024-07-29 DOI:10.1007/s12020-024-03976-0

Jing-Xuan Xu, Yuan-Yuan Chen, Lu-Nan Qi, Yu-Chong Peng

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Abstract

Purpose: A potential association between breast (BC) and thyroid cancer (TC) has been observed. We investigated if the relationship between BC and TC is causal using bidirectional Mendelian randomization (MR) in Asian and European populations.

Methods: BC-linked single nucleotide polymorphisms (SNPs) were acquired from a genome-wide association study (GWAS) conducted by the Breast Cancer Association Consortium and Biobank Japan. The most recent TC GWAS data were obtained from the FinnGen Project and National Biobank of Korea. We assessed the potential causal relationship between BC and TC using various MR methods, including inverse-variance-weighting (IVW). Sensitivity, heterogeneity, and pleiotropic tests were performed to assess reliability.

Results: We found a bidirectional causal association between BC and TC within Europeans (IVW, TC on BC: odds ratio [OR] 1.090, 95% confidence interval [CI]: 1.012-1.173, P = 0.023; BC on TC: OR 1.265, 95% CI: 1.158-1.381, P < 0.001). A one-way causal relationship between BC susceptibility and TC risk was found in Asians (IVW BC on TC: OR 2.274, 95% CI: 2.089-2.475, P < 0.001). Subsequently, we identified a noteworthy bidirectional causal relationship between estrogen receptor (ER)-positive BC and TC (IVW, TC on ER-positive BC: OR 1.104, 95% CI: 1.001-1.212, P = 0.038; ER-positive BC on TC: OR 1.223, 95%CI: 1.072-1.395, P = 0.003), but not ER-negative BC and TC in Europeans.

Conclusion: We revealed a reciprocal causal association between ER-positive BC and TC. These findings establish a theoretical framework for the simultaneous surveillance and treatment of BC and TC.

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乳腺癌与甲状腺癌因果关系调查：一组双样本双向孟德尔随机研究。

目的：已观察到乳腺癌（BC）与甲状腺癌（TC）之间存在潜在关联。我们在亚洲和欧洲人群中使用双向孟德尔随机化（MR）方法研究了乳腺癌和甲状腺癌之间是否存在因果关系：方法：与 BC 相关的单核苷酸多态性（SNPs）来自乳腺癌协会联盟（Breast Cancer Association Consortium）和日本生物库（Biobank Japan）开展的全基因组关联研究（GWAS）。最新的 TC GWAS 数据来自芬兰基因项目（FinnGen Project）和韩国国家生物库（National Biobank of Korea）。我们使用各种 MR 方法（包括逆方差加权法（IVW））评估了 BC 与 TC 之间的潜在因果关系。为了评估可靠性，我们进行了敏感性、异质性和多向性测试：结果：我们发现欧洲人的 BC 与 TC 之间存在双向因果关系（IVW，TC 与 BC 的比值比 [OR] 1.090，95% 置信区间 [CI]：1.012-1.173）：1.012-1.173, P = 0.023; BC on TC: OR 1.265, 95% CI: 1.158-1.381, P 结论：我们发现ER阳性BC与TC之间存在互为因果的关系。这些发现为同时监测和治疗 BC 和 TC 建立了一个理论框架。

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来源期刊

Endocrine ENDOCRINOLOGY & METABOLISM-

CiteScore

6.50

自引率

5.40%

发文量

295

审稿时长

1.5 months

期刊介绍： Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology. Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted. Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.

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