The cervical cancer related distribution, coinfection and risk of 15 HPV types in Baoan, Shenzhen, in 2017-2023.

IF 4 3区医学 Q2 VIROLOGY

Virology Journal Pub Date : 2024-07-29 DOI:10.1186/s12985-024-02439-2

Rukai Li, Weiwei Meng, Yunhai Zuo, Yanli Xu, Shaonan Wu

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引用次数: 0

Abstract

Cervical cancer is one of the most common malignant tumours. Human papillomavirus (HPV) infection is the main cause of this cancer so that it could be prevented by screening and early treatment. Developing reginal screen protocols of maximum public health efficacy requires in-depth understandings of local HPV distribution and consequential cancer risks. Therefore, test results of HPV genotyping, cytology testing (TCT) and colposcopy inspection with biopsy were collected in this retrospective research. Data included by this research involved 63,906 women received screen related tests from Shenzhen Baoan Shiyan People's Hospital and the subsidiary institutes between 2017.01 and 2023.05. 10,238 colposcopies were performed in this period collecting 8,716 samples and 814 high-grade CIN were discovered. Within the 763 high-grade CIN cases with both TCT and HPV testing results, 232 were tested cytologically normal but only 30 were negative in HPV test. Besides, the rates of high-grade CIN observed in coinfection were all lower than the estimated rates generated from related single infection. HPV 52, 58 and 16 were found to be the most common types in Baoan, Shenzhen. The result also suggested that HPV coinfections should not increase risk for cervical cancers.

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2017-2023 年深圳宝安 15 种 HPV 类型与宫颈癌相关的分布、合并感染及风险。

宫颈癌是最常见的恶性肿瘤之一。人类乳头瘤病毒（HPV）感染是导致这种癌症的主要原因，因此可以通过筛查和早期治疗来预防。要制定具有最大公共卫生效果的常规筛查方案，就必须深入了解当地的 HPV 分布情况以及由此引发的癌症风险。因此，这项回顾性研究收集了 HPV 基因分型、细胞学检测（TCT）和阴道镜检查及活检的检测结果。本研究收集的数据涉及 2017.01 至 2023.05 年间在深圳市宝安区石岩人民医院及其附属机构接受筛查相关检查的 63906 名女性。在此期间，共进行了 10238 次阴道镜检查，采集了 8716 份样本，发现了 814 例高级别 CIN。在763例同时具有TCT和HPV检测结果的高级别CIN病例中，232例细胞学检测正常，但只有30例HPV检测阴性。此外，在合并感染中观察到的高级别 CIN 发生率均低于相关单一感染的估计发生率。在深圳宝安，HPV 52、58 和 16 是最常见的类型。结果还表明，HPV 合并感染不会增加宫颈癌的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Virology Journal 医学-病毒学

CiteScore

7.40

自引率

2.10%

发文量

186

审稿时长

1 months

期刊介绍： Virology Journal is an open access, peer reviewed journal that considers articles on all aspects of virology, including research on the viruses of animals, plants and microbes. The journal welcomes basic research as well as pre-clinical and clinical studies of novel diagnostic tools, vaccines and anti-viral therapies. The Editorial policy of Virology Journal is to publish all research which is assessed by peer reviewers to be a coherent and sound addition to the scientific literature, and puts less emphasis on interest levels or perceived impact.