Long-term functional, anatomical outcome, and qualitative analysis by OCTA, as a predictor of disease recurrences in patients with choroidal neovascularization secondary to angioid streaks.

IF 1.9 Q2 OPHTHALMOLOGY
Raul Velez-Montoya, Hillary K Osorio-Landa, K Carolina Franco-Ramirez, Victor Martínez-Pacheco, J Abel Ramirez-Estudillo, Jaime Francisco Rosales-Padrón, Gerardo Ledesma-Gil, Jans Fromow-Guerra
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引用次数: 0

Abstract

Background: To report the risk of exudation recurrence and long-term outcomes in patients with choroidal neovascularization secondary to angioid streaks, according to its morphology and characteristics by optical coherence tomography angiography.

Methods: Retrospective analysis of electronic medical records from three hospitals. We enrolled patients with a clinical diagnosis of angioid streaks choroidal neovascularization that had a minimum follow-up of 12 months. From each record, we extracted general demographic data, best corrected visual acuity (baseline, before and after each disease recurrence and last on file), type of treatment, time between last intravitreal injection and disease recurrence, and classification of the neovascular lesion morphology by optical coherence tomography, and optical coherence tomography angiography. Patients with myopic choroidal neovascularization were used as controls. Interobserver agreement was assessed with a Cohen-Kappa test. The Odds ratio was calculated with a chi2 test for significance. Visual acuity change through time was evaluated with an ANOVA for repeated measurements with an alpha value of 0.05 for statistical significance.

Results: We enrolled 30 patients in the study group and 14 in the control group. In the study group, the baseline and final BCVA were 0.861 ± 0.59 and 1.095 ± 0.61 logMAR (p = 0.1) respectively.

Control group: 1.045 ± 0.57 and 0.617 ± 0.53 logMAR (p < 0.05). In the study group, the predominant CNV type by OCTA was mixed (37%), and interlacing (57%) in the control group. Mixed and cog-wheel patterns at baseline had increased Odds for recurrence in the study group (p = 0.09). Patients in the study group required more intravitreal injections on each recurrence episode to achieve disease control (3.5 ± 1.5 vs.1.4 ± 0.2, p < 0.01).

Conclusions: The benefits of anti-VEGF treatment are lost over time in patients with angioid streaks and CNV. Lesion characteristics by optical coherence tomography angiography could help physicians predict the risk of recurrence.

Trial registration: Retrospective registered, and IRB approved.

通过 OCTA 对脉络膜新生血管继发血管样条纹患者的长期功能、解剖结果和定性分析,预测疾病复发。
背景:根据光学相干断层血管造影的形态和特征,报告继发于血管样条纹的脉络膜新生血管患者的渗出复发风险和长期预后:方法:对三家医院的电子病历进行回顾性分析。我们选取了临床诊断为血管样条纹脉络膜新生血管且随访至少 12 个月的患者。我们从每份病历中提取了一般人口统计学数据、最佳矫正视力(基线、每次疾病复发前和复发后以及最后一次存档)、治疗类型、最后一次玻璃体内注射与疾病复发之间的时间,以及通过光学相干断层扫描和光学相干断层血管造影对新生血管病变形态进行的分类。近视脉络膜新生血管患者作为对照组。采用 Cohen-Kappa 检验评估观察者之间的一致性。用chi2检验计算Odds比的显著性。用重复测量方差分析评估视力随时间的变化,统计学意义的α值为0.05:研究组有 30 名患者,对照组有 14 名患者。研究组的基线和最终 BCVA 分别为 0.861 ± 0.59 和 1.095 ± 0.61 logMAR (p = 0.1):对照组:1.045 ± 0.57 和 0.617 ± 0.53 logMAR(p 结论:抗 VEGF 治疗的疗效与对照组相同:血管样条纹和 CNV 患者的抗 VEGF 治疗效果会随着时间的推移而消失。通过光学相干断层血管造影检查病变特征可帮助医生预测复发风险:试验注册:回顾性注册,已获国际注册研究委员会批准。
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来源期刊
CiteScore
3.50
自引率
4.30%
发文量
81
审稿时长
19 weeks
期刊介绍: International Journal of Retina and Vitreous focuses on the ophthalmic subspecialty of vitreoretinal disorders. The journal presents original articles on new approaches to diagnosis, outcomes of clinical trials, innovations in pharmacological therapy and surgical techniques, as well as basic science advances that impact clinical practice. Topical areas include, but are not limited to: -Imaging of the retina, choroid and vitreous -Innovations in optical coherence tomography (OCT) -Small-gauge vitrectomy, retinal detachment, chromovitrectomy -Electroretinography (ERG), microperimetry, other functional tests -Intraocular tumors -Retinal pharmacotherapy & drug delivery -Diabetic retinopathy & other vascular diseases -Age-related macular degeneration (AMD) & other macular entities
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