Fast and efficient extraction and determination of nonsteroidal anti-inflammatory drugs using poly(8-hydroxyquinoline)-coated magnetic graphene oxide nanocomposite prior to capillary electrophoresis analysis in wastewater, breast milk, and urine samples

IF 3 3区生物学 Q2 BIOCHEMICAL RESEARCH METHODS

ELECTROPHORESIS Pub Date : 2024-07-30 DOI:10.1002/elps.202400023

Abolfath Shahsavani, Ali Reza Fakhari

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引用次数: 0

Abstract

In this study, magnetic graphene oxide coated with poly(8-hydroxyquinoline) was successfully synthesized, characterized, and utilized as a novel sorbent for the ultrasonic-assisted dispersive magnetic solid-phase extraction of naproxen and ibuprofen. These analytes served as representative analytes for two nonsteroidal anti-inflammatory drugs in various real samples. Characterization techniques, such as IR, X-ray powder diffraction, field emission scanning electron microscopy, energy-dispersive X-ray-mapping, and Brunauer-Emmett-Teller (BET), were used to confirm the correctness synthesis and preparation of the nanocomposites. Effective parameters on the extraction efficiency were investigated to maximize the analytical performance of the developed method. The dynamic range (1–1000 µg L⁻¹), coefficients of determination (R² ≥ 0.997), the limits of detection (0.3–1.0 µg L⁻¹), and limit of quantification (1.0–3.0 µg L⁻¹), intra-day and inter-day precisions (3.5%–7.2%) were achieved. The method validation results showed extraction recovery ranging from 80.4% to 96.0% and preconcentration factors ranging from 137 to 140.

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在对废水、母乳和尿液样品进行毛细管电泳分析之前，使用聚（8-羟基喹啉）涂层磁性氧化石墨烯纳米复合材料快速高效地提取和测定非甾体类消炎药。

本研究成功合成、表征了包覆聚（8-羟基喹啉）的磁性氧化石墨烯，并将其用作超声辅助分散磁性固相萃取萘普生和布洛芬的新型吸附剂。这些分析物是各种实际样品中两种非甾体抗炎药物的代表性分析物。利用红外光谱、X 射线粉末衍射、场发射扫描电子显微镜、能量色散 X 射线图谱和布鲁纳-艾美特-泰勒（BET）等表征技术确认了纳米复合材料合成和制备的正确性。研究了影响萃取效率的有效参数，以最大限度地提高所开发方法的分析性能。该方法的动态范围（1-1000 µg L-1）、测定系数（R2 ≥ 0.997）、检出限（0.3-1.0 µg L-1）、定量限（1.0-3.0 µg L-1）、日内和日间精密度（3.5%-7.2%）均达到了要求。方法验证结果表明萃取回收率为 80.4% 至 96.0%，预浓缩因子为 137 至 140。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ELECTROPHORESIS 生物-分析化学

CiteScore

6.30

自引率

13.80%

发文量

244

审稿时长

1.9 months

期刊介绍： ELECTROPHORESIS is an international journal that publishes original manuscripts on all aspects of electrophoresis, and liquid phase separations (e.g., HPLC, micro- and nano-LC, UHPLC, micro- and nano-fluidics, liquid-phase micro-extractions, etc.). Topics include new or improved analytical and preparative methods, sample preparation, development of theory, and innovative applications of electrophoretic and liquid phase separations methods in the study of nucleic acids, proteins, carbohydrates natural products, pharmaceuticals, food analysis, environmental species and other compounds of importance to the life sciences. Papers in the areas of microfluidics and proteomics, which are not limited to electrophoresis-based methods, will also be accepted for publication. Contributions focused on hyphenated and omics techniques are also of interest. Proteomics is within the scope, if related to its fundamentals and new technical approaches. Proteomics applications are only considered in particular cases. Papers describing the application of standard electrophoretic methods will not be considered. Papers on nanoanalysis intended for publication in ELECTROPHORESIS should focus on one or more of the following topics: • Nanoscale electrokinetics and phenomena related to electric double layer and/or confinement in nano-sized geometry • Single cell and subcellular analysis • Nanosensors and ultrasensitive detection aspects (e.g., involving quantum dots, "nanoelectrodes" or nanospray MS) • Nanoscale/nanopore DNA sequencing (next generation sequencing) • Micro- and nanoscale sample preparation • Nanoparticles and cells analyses by dielectrophoresis • Separation-based analysis using nanoparticles, nanotubes and nanowires.